Precise nanomedicine for intelligent therapy of cancer

Huabing Chen; Zhanjun Gu; Hongwei An; Chunying Chen; Jie Chen; Ran Cui; Siqin Chen; Weihai Chen; Xuesi Chen; Xiaoyuan Chen; Zhuo Chen; Baoquan Ding; Qian Dong; Qin Fan; Ting Fu; Dayong Hou; Qiao Jiang; Hengte Ke; Xiqun Jiang; Gang Liu; Suping Li; Tianyu Li; Zhuang Liu; Guangjun Nie; Muhammad Ovais; Daiwen Pang; Nasha Qiu; Youqing Shen; Huayu Tian; Chao Wang; Hao Wang; Ziqi Wang; Huaping Xu; Jiang Fei Xu; Xiangliang Yang; Shuang Zhu; Xianchuang Zheng; Xianzheng Zhang; Yanbing Zhao; Weihong Tan; Xi Zhang; Yuliang Zhao

doi:10.1007/s11426-018-9397-5

Precise nanomedicine for intelligent therapy of cancer

Huabing Chen, Zhanjun Gu, Hongwei An, Chunying Chen, Jie Chen, Ran Cui, Siqin Chen, Weihai Chen, Xuesi Chen, Xiaoyuan Chen, Zhuo Chen, Baoquan Ding, Qian Dong, Qin Fan, Ting Fu, Dayong Hou, Qiao Jiang, Hengte Ke, Xiqun Jiang, Gang LiuSuping Li, Tianyu Li, Zhuang Liu, Guangjun Nie, Muhammad Ovais, Daiwen Pang, Nasha Qiu, Youqing Shen, Huayu Tian, Chao Wang, Hao Wang, Ziqi Wang, Huaping Xu, Jiang Fei Xu, Xiangliang Yang, Shuang Zhu, Xianchuang Zheng, Xianzheng Zhang, Yanbing Zhao, Weihong Tan, Xi Zhang, Yuliang Zhao

Houston Methodist

Research output: Contribution to journal › Review article › peer-review

384 Scopus citations

Abstract

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

Original language	English (US)
Pages (from-to)	1503-1552
Number of pages	50
Journal	Science China Chemistry
Volume	61
Issue number	12
DOIs	https://doi.org/10.1007/s11426-018-9397-5
State	Published - Dec 1 2018

Keywords

cancer imaging
cancer therapy
intelligent therapy
nanomedicine
nanoparticles

ASJC Scopus subject areas

General Chemistry

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10.1007/s11426-018-9397-5

Cite this

Chen, H, Gu, Z, An, H, Chen, C, Chen, J, Cui, R, Chen, S, Chen, W, Chen, X, Chen, X, Chen, Z, Ding, B, Dong, Q, Fan, Q, Fu, T, Hou, D, Jiang, Q, Ke, H, Jiang, X, Liu, G, Li, S, Li, T, Liu, Z, Nie, G, Ovais, M, Pang, D, Qiu, N, Shen, Y, Tian, H, Wang, C, Wang, H, Wang, Z, Xu, H, Xu, JF, Yang, X, Zhu, S, Zheng, X, Zhang, X, Zhao, Y, Tan, W, Zhang, X & Zhao, Y 2018, 'Precise nanomedicine for intelligent therapy of cancer', Science China Chemistry, vol. 61, no. 12, pp. 1503-1552. https://doi.org/10.1007/s11426-018-9397-5

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abstract = "Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.",

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author = "Huabing Chen and Zhanjun Gu and Hongwei An and Chunying Chen and Jie Chen and Ran Cui and Siqin Chen and Weihai Chen and Xuesi Chen and Xiaoyuan Chen and Zhuo Chen and Baoquan Ding and Qian Dong and Qin Fan and Ting Fu and Dayong Hou and Qiao Jiang and Hengte Ke and Xiqun Jiang and Gang Liu and Suping Li and Tianyu Li and Zhuang Liu and Guangjun Nie and Muhammad Ovais and Daiwen Pang and Nasha Qiu and Youqing Shen and Huayu Tian and Chao Wang and Hao Wang and Ziqi Wang and Huaping Xu and Xu, {Jiang Fei} and Xiangliang Yang and Shuang Zhu and Xianchuang Zheng and Xianzheng Zhang and Yanbing Zhao and Weihong Tan and Xi Zhang and Yuliang Zhao",

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doi = "10.1007/s11426-018-9397-5",

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AU - Chen, Huabing

AU - Gu, Zhanjun

AU - An, Hongwei

AU - Chen, Chunying

AU - Chen, Jie

AU - Cui, Ran

AU - Chen, Siqin

AU - Chen, Weihai

AU - Chen, Xuesi

AU - Chen, Xiaoyuan

AU - Chen, Zhuo

AU - Ding, Baoquan

AU - Dong, Qian

AU - Fan, Qin

AU - Fu, Ting

AU - Hou, Dayong

AU - Jiang, Qiao

AU - Ke, Hengte

AU - Jiang, Xiqun

AU - Liu, Gang

AU - Li, Suping

AU - Li, Tianyu

AU - Liu, Zhuang

AU - Nie, Guangjun

AU - Ovais, Muhammad

AU - Pang, Daiwen

AU - Qiu, Nasha

AU - Shen, Youqing

AU - Tian, Huayu

AU - Wang, Chao

AU - Wang, Hao

AU - Wang, Ziqi

AU - Xu, Huaping

AU - Xu, Jiang Fei

AU - Yang, Xiangliang

AU - Zhu, Shuang

AU - Zheng, Xianchuang

AU - Zhang, Xianzheng

AU - Zhao, Yanbing

AU - Tan, Weihong

AU - Zhang, Xi

AU - Zhao, Yuliang

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

AB - Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

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KW - cancer therapy

KW - intelligent therapy

KW - nanomedicine

KW - nanoparticles

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Precise nanomedicine for intelligent therapy of cancer

Abstract

Keywords

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