Precise nanomedicine for intelligent therapy of cancer

Huabing Chen, Zhanjun Gu, Hongwei An, Chunying Chen, Jie Chen, Ran Cui, Siqin Chen, Weihai Chen, Xuesi Chen, Xiaoyuan Chen, Zhuo Chen, Baoquan Ding, Qian Dong, Qin Fan, Ting Fu, Dayong Hou, Qiao Jiang, Hengte Ke, Xiqun Jiang, Gang LiuSuping Li, Tianyu Li, Zhuang Liu, Guangjun Nie, Muhammad Ovais, Daiwen Pang, Nasha Qiu, Youqing Shen, Huayu Tian, Chao Wang, Hao Wang, Ziqi Wang, Huaping Xu, Jiang Fei Xu, Xiangliang Yang, Shuang Zhu, Xianchuang Zheng, Xianzheng Zhang, Yanbing Zhao, Weihong Tan, Xi Zhang, Yuliang Zhao

Research output: Contribution to journalReview article

179 Scopus citations

Abstract

Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations.

Original languageEnglish (US)
Pages (from-to)1503-1552
Number of pages50
JournalScience China Chemistry
Volume61
Issue number12
DOIs
StatePublished - Dec 1 2018

Keywords

  • cancer imaging
  • cancer therapy
  • intelligent therapy
  • nanomedicine
  • nanoparticles

ASJC Scopus subject areas

  • Chemistry(all)

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