Pre-transplant utilization of sorafenib is not associated with increased complications after liver transplantation

Catherine T. Frenette, Maha Boktour, Sherilyn Gordon Burroughs, Ahmed Kaseb, Thomas A. Aloia, Joseph Galati, A. Osama Gaber, Howard Paul Monsour, Jr., R. Mark Ghobrial

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Hepatocellular carcinoma (HCC) is increasing in incidence, resulting in approximately 35% of orthotopic liver transplantation (OLT) performed each year. Sorafenib (SOR) is a multi-kinase inhibitor that is approved for the treatment of unresectable HCC. Concerns have been raised regarding the safety of SOR in patients undergoing major surgery. We retrospectively reviewed 79 consecutive patients with HCC receiving OLT. Patient data were compared for those who received SOR pre-OLT with those who did not. SOR was continued until time of transplant. During this time period, 15 patients received SOR pre-OLT and 64 did not. The two groups were similar with regards to demographic and clinical data. SOR patients were more likely to have larger tumors, more tumor nodules, and be outside of Milan criteria. The rate of recurrence of HCC was not different between the groups (13% in SOR group, 11% in no-SOR group). Surgical complications were not increased in patients receiving SOR prior to OLT. Survival rate was also similar between the two groups (median follow-up 19.7 months). In this small cohort of patients, use of SOR prior to liver transplantation does not confer an increased risk of surgical complications, even when continued until the day of surgery.

Original languageEnglish (US)
Pages (from-to)734-739
Number of pages6
JournalTransplant International
Volume26
Issue number7
DOIs
StatePublished - Jul 1 2013

Keywords

  • hepatocellular carcinoma
  • liver cancer
  • orthotopic liver transplantation
  • sorafenib
  • surgical complications

ASJC Scopus subject areas

  • Transplantation

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