Abstract
This study examined pre-surgical depressed mood as a predictor of post-surgical memory change in adults who underwent temporal lobe resections (TLRs; n = 211). Patients completed the Wechsler Memory Scale-III and Beck Depression Inventory-Second Edition (BDI-II) before and after TLR (left = 110, right = 101) and were divided into two groups (clinically elevated depressive symptoms or not depressed) based on BDI-II score. Left-TLR patients with poorer pre-surgical mood had greater verbal memory declines after surgery compared with nondepressed left- or right-TLR patients and right-TLR patients with poor mood. Further, pre-surgical BDI-II score demonstrated incremental validity in predicting post-surgical memory change in left-TLR patients beyond pre-surgical memory scores. Differences in seizure outcome and post-surgical mood change could not account for memory decline. Results suggest that elevated pre-surgical depressive symptomatology is a risk factor for post-surgical memory decline and indicate that mood should be considered when advising patients about cognitive risks associated with temporal lobectomy. Results are discussed in terms of poor pre-surgical mood as an indicator of reduced cognitive reserve.
Original language | English (US) |
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Pages (from-to) | 739-745 |
Number of pages | 7 |
Journal | Archives of Clinical Neuropsychology |
Volume | 26 |
Issue number | 8 |
DOIs | |
State | Published - Dec 2011 |
Keywords
- Depression
- Epilepsy
- Learning and memory
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
- Neuropsychology and Physiological Psychology