Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine in C57BL/6 mice

Ling Long Zou, Jing Xu, Joseph Jankovic, Yi He, Stanley H. Appel, Weidong Le

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

Pramipexole has been showed to protect cultured dopaminergic (DAergic) cells against free radical-induced cytotoxicity. To test if pramipexole is protective against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- mediated nigral DAergic injury in vivo and if such protection is related to inhibition of lipid peroxidation, DAergic function and lipid peroxidation were determined in MPTP-treated C57BL/6 mice. We reported that MPTP administration induced a 38.1% increase of lipid peroxidation product thiobarbituric acid reactive substance (TBARS) in nigra, a 46.7% decrease of tyrosine hydroxylase-positive nigral DAergic neurons and a 59.4% reduction of striatal DA levels. However, pramipexole treatment significantly inhibited the TBARS production by 76%, and attenuated the MPTP-induced decreases in nigral DAergic neurons and striatal DA levels by about 50%. This study suggests that pramipexole can inhibit free radical-mediated lipid peroxidation and protect MPTP-induced nigral injury. (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)167-170
Number of pages4
JournalNeuroscience Letters
Volume281
Issue number2-3
DOIs
StatePublished - Mar 10 2000

Keywords

  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Dopamine
  • Lipid peroxidation
  • Neuroprotection
  • Parkinson's disease
  • Pramipexole

ASJC Scopus subject areas

  • Neuroscience(all)

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