Powerful immunosuppression mediated by interleukin 2-activated, nonantigen-specific, or H-2-restricted THY-1+ CD8+ cells

Guillermo Torre-Amione, Rebecca Tuetken, Donald A. Rowley

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Normal spleen cells cultured in high or low concentrations of interleukin (IL) 2 for 3 days contain Thy-1+ CD4- CD8+ cells that powerfully suppress primary but not ongoing or active lymphocyte responses. The precursors of these cells are Thy-1+AGM-1- and are absent or present in greatly diminished numbers in athymic and scid mice. Suppression is neither antigen nor H-2 restricted and apparently results from reversible inactivation of resting lymphocytes. Comparable Thy-1+ CD8+ suppressor cells were also recovered from normal spleen cells cultured for 3 days with anti-CD3 antibody without added IL-2, indicating that these cells can be activated during the course of immune responses. Such cells may prevent local recruitment/activation of lymphocytes specific for new epitopes that may be expressed sequentially by proliferating tumor cells or infectious organisms.

Original languageEnglish (US)
Pages (from-to)50-63
Number of pages14
JournalCellular Immunology
Volume124
Issue number1
DOIs
StatePublished - Nov 1989

ASJC Scopus subject areas

  • Immunology

Fingerprint Dive into the research topics of 'Powerful immunosuppression mediated by interleukin 2-activated, nonantigen-specific, or H-2-restricted THY-1<sup>+</sup> CD8<sup>+</sup> cells'. Together they form a unique fingerprint.

Cite this