Potential new therapies for pediatric diffuse intrinsic pontine glioma

Wenyong Long, Yang Yi, Shen Chen, Qi Cao, Wei Zhao, Qing Liu

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems.

Original languageEnglish (US)
Article number495
JournalFrontiers in Pharmacology
Volume8
Issue numberJUL
DOIs
StatePublished - Jul 25 2017

Keywords

  • DIPG
  • Epigenetic therapy
  • H3K27M
  • Immunotherapy
  • Nanoparticles
  • Stem cells

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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