Potential new therapies for pediatric diffuse intrinsic pontine glioma

Wenyong Long; Yang Yi; Shen Chen; Qi Cao; Wei Zhao; Qing Liu

doi:10.3389/fphar.2017.00495

Potential new therapies for pediatric diffuse intrinsic pontine glioma

Wenyong Long, Yang Yi, Shen Chen, Qi Cao, Wei Zhao, Qing Liu

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems.

Original language	English (US)
Article number	495
Journal	Frontiers in Pharmacology
Volume	8
Issue number	JUL
DOIs	https://doi.org/10.3389/fphar.2017.00495
State	Published - Jul 25 2017

Keywords

DIPG
Epigenetic therapy
H3K27M
Immunotherapy
Nanoparticles
Stem cells

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.3389/fphar.2017.00495

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title = "Potential new therapies for pediatric diffuse intrinsic pontine glioma",

abstract = "Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems.",

keywords = "DIPG, Epigenetic therapy, H3K27M, Immunotherapy, Nanoparticles, Stem cells",

author = "Wenyong Long and Yang Yi and Shen Chen and Qi Cao and Wei Zhao and Qing Liu",

note = "Funding Information: This work was supported by National Natural Science Foundation of China (No. 81572766), Guangdong Innovative and Entepreneurial Research Team Program (No. 2016ZT06S029), and SYSU Young Teachers Training Program (No. 16YKZD14). Publisher Copyright: {\textcopyright} 2017 Long, Yi, Chen, Cao, Zhao and Liu.",

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AU - Long, Wenyong

AU - Yi, Yang

AU - Chen, Shen

AU - Cao, Qi

AU - Zhao, Wei

AU - Liu, Qing

N1 - Funding Information: This work was supported by National Natural Science Foundation of China (No. 81572766), Guangdong Innovative and Entepreneurial Research Team Program (No. 2016ZT06S029), and SYSU Young Teachers Training Program (No. 16YKZD14). Publisher Copyright: © 2017 Long, Yi, Chen, Cao, Zhao and Liu.

PY - 2017/7/25

Y1 - 2017/7/25

N2 - Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems.

AB - Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems.

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KW - Nanoparticles

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Potential new therapies for pediatric diffuse intrinsic pontine glioma

Abstract

Keywords

ASJC Scopus subject areas

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