Potential biomarkers of Parkinson's disease revealed by plasma metabolic profiling

Huiyuan Zhao, Cui Wang, Nan Zhao, Wenxue Li, Zhaofei Yang, Xinxin Liu, Weidong Le, Xiaozhe Zhang

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


The plasma of Parkinson's disease (PD) patients may contain various altered metabolites associated with the risk or progression of the disease. Characterization of the abnormal metabolic pattern in PD plasma is therefore critical for the search for potential PD biomarkers. We collected blood plasma samples from PD patients and used an LC-MS based metabolomics approach to identify 17 metabolites with significantly altered levels. Metabolic network analysis was performed to place the metabolites linked to different pathways. The metabolic pathways involved were associated with tyrosine biosynthesis, glycerol phospholipid metabolism, carnitine metabolism and bile acid biosynthesis, within which carnitine and bile acid metabolites as potential biomarkers are first time reported. These abnormal metabolic changes in the plasma of patients with PD were mainly related to lipid metabolism and mitochondrial function.

Original languageEnglish (US)
Pages (from-to)101-108
Number of pages8
JournalJournal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
StatePublished - Apr 1 2018


  • Metabolites
  • Metabolomics
  • Parkinson's disease
  • Pathway
  • Plasma

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry
  • Cell Biology


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