Abstract
The plasma of Parkinson's disease (PD) patients may contain various altered metabolites associated with the risk or progression of the disease. Characterization of the abnormal metabolic pattern in PD plasma is therefore critical for the search for potential PD biomarkers. We collected blood plasma samples from PD patients and used an LC-MS based metabolomics approach to identify 17 metabolites with significantly altered levels. Metabolic network analysis was performed to place the metabolites linked to different pathways. The metabolic pathways involved were associated with tyrosine biosynthesis, glycerol phospholipid metabolism, carnitine metabolism and bile acid biosynthesis, within which carnitine and bile acid metabolites as potential biomarkers are first time reported. These abnormal metabolic changes in the plasma of patients with PD were mainly related to lipid metabolism and mitochondrial function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 101-108 |
| Number of pages | 8 |
| Journal | Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences |
| Volume | 1081-1082 |
| DOIs | |
| State | Published - Apr 1 2018 |
Keywords
- Metabolites
- Metabolomics
- Parkinson's disease
- Pathway
- Plasma
- Reproducibility of Results
- Humans
- Middle Aged
- Male
- Chromatography, High Pressure Liquid
- Case-Control Studies
- Parkinson Disease/blood
- Sensitivity and Specificity
- Biomarkers/blood
- Female
- Aged
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- Cluster Analysis
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Clinical Biochemistry
- Cell Biology