Potential biomarkers of Parkinson's disease revealed by plasma metabolic profiling

Huiyuan Zhao; Cui Wang; Nan Zhao; Wenxue Li; Zhaofei Yang; Xinxin Liu; Weidong Le; Xiaozhe Zhang

doi:10.1016/j.jchromb.2018.01.025

Potential biomarkers of Parkinson's disease revealed by plasma metabolic profiling

Huiyuan Zhao, Cui Wang, Nan Zhao, Wenxue Li, Zhaofei Yang, Xinxin Liu, Weidong Le, Xiaozhe Zhang

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

The plasma of Parkinson's disease (PD) patients may contain various altered metabolites associated with the risk or progression of the disease. Characterization of the abnormal metabolic pattern in PD plasma is therefore critical for the search for potential PD biomarkers. We collected blood plasma samples from PD patients and used an LC-MS based metabolomics approach to identify 17 metabolites with significantly altered levels. Metabolic network analysis was performed to place the metabolites linked to different pathways. The metabolic pathways involved were associated with tyrosine biosynthesis, glycerol phospholipid metabolism, carnitine metabolism and bile acid biosynthesis, within which carnitine and bile acid metabolites as potential biomarkers are first time reported. These abnormal metabolic changes in the plasma of patients with PD were mainly related to lipid metabolism and mitochondrial function.

Original language	English (US)
Pages (from-to)	101-108
Number of pages	8
Journal	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume	1081-1082
DOIs	https://doi.org/10.1016/j.jchromb.2018.01.025
State	Published - Apr 1 2018

Keywords

Metabolites
Metabolomics
Parkinson's disease
Pathway
Plasma

ASJC Scopus subject areas

Analytical Chemistry
Biochemistry
Clinical Biochemistry
Cell Biology

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10.1016/j.jchromb.2018.01.025

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title = "Potential biomarkers of Parkinson's disease revealed by plasma metabolic profiling",

abstract = "The plasma of Parkinson's disease (PD) patients may contain various altered metabolites associated with the risk or progression of the disease. Characterization of the abnormal metabolic pattern in PD plasma is therefore critical for the search for potential PD biomarkers. We collected blood plasma samples from PD patients and used an LC-MS based metabolomics approach to identify 17 metabolites with significantly altered levels. Metabolic network analysis was performed to place the metabolites linked to different pathways. The metabolic pathways involved were associated with tyrosine biosynthesis, glycerol phospholipid metabolism, carnitine metabolism and bile acid biosynthesis, within which carnitine and bile acid metabolites as potential biomarkers are first time reported. These abnormal metabolic changes in the plasma of patients with PD were mainly related to lipid metabolism and mitochondrial function.",

keywords = "Metabolites, Metabolomics, Parkinson's disease, Pathway, Plasma",

author = "Huiyuan Zhao and Cui Wang and Nan Zhao and Wenxue Li and Zhaofei Yang and Xinxin Liu and Weidong Le and Xiaozhe Zhang",

note = "Funding Information: This work is supported by the Ministry of Science and Technology of the People's Republic of China [2015DFG42460]; National Science Foundation [21475128]; and Chinese Academy of Science [100Talent Project]. Funding Information: This work is supported by the Ministry of Science and Technology of the People's Republic of China [ 2015DFG42460 ]; National Science Foundation [ 21475128 ]; and Chinese Academy of Science [100Talent Project]. Publisher Copyright: {\textcopyright} 2018 Elsevier B.V. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2018",

month = apr,

day = "1",

doi = "10.1016/j.jchromb.2018.01.025",

language = "English (US)",

volume = "1081-1082",

pages = "101--108",

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T1 - Potential biomarkers of Parkinson's disease revealed by plasma metabolic profiling

AU - Zhao, Huiyuan

AU - Wang, Cui

AU - Zhao, Nan

AU - Li, Wenxue

AU - Yang, Zhaofei

AU - Liu, Xinxin

AU - Le, Weidong

AU - Zhang, Xiaozhe

N1 - Funding Information: This work is supported by the Ministry of Science and Technology of the People's Republic of China [2015DFG42460]; National Science Foundation [21475128]; and Chinese Academy of Science [100Talent Project]. Funding Information: This work is supported by the Ministry of Science and Technology of the People's Republic of China [ 2015DFG42460 ]; National Science Foundation [ 21475128 ]; and Chinese Academy of Science [100Talent Project]. Publisher Copyright: © 2018 Elsevier B.V. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - The plasma of Parkinson's disease (PD) patients may contain various altered metabolites associated with the risk or progression of the disease. Characterization of the abnormal metabolic pattern in PD plasma is therefore critical for the search for potential PD biomarkers. We collected blood plasma samples from PD patients and used an LC-MS based metabolomics approach to identify 17 metabolites with significantly altered levels. Metabolic network analysis was performed to place the metabolites linked to different pathways. The metabolic pathways involved were associated with tyrosine biosynthesis, glycerol phospholipid metabolism, carnitine metabolism and bile acid biosynthesis, within which carnitine and bile acid metabolites as potential biomarkers are first time reported. These abnormal metabolic changes in the plasma of patients with PD were mainly related to lipid metabolism and mitochondrial function.

AB - The plasma of Parkinson's disease (PD) patients may contain various altered metabolites associated with the risk or progression of the disease. Characterization of the abnormal metabolic pattern in PD plasma is therefore critical for the search for potential PD biomarkers. We collected blood plasma samples from PD patients and used an LC-MS based metabolomics approach to identify 17 metabolites with significantly altered levels. Metabolic network analysis was performed to place the metabolites linked to different pathways. The metabolic pathways involved were associated with tyrosine biosynthesis, glycerol phospholipid metabolism, carnitine metabolism and bile acid biosynthesis, within which carnitine and bile acid metabolites as potential biomarkers are first time reported. These abnormal metabolic changes in the plasma of patients with PD were mainly related to lipid metabolism and mitochondrial function.

KW - Metabolites

KW - Metabolomics

KW - Parkinson's disease

KW - Pathway

KW - Plasma

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ER -

Potential biomarkers of Parkinson's disease revealed by plasma metabolic profiling

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Keywords

ASJC Scopus subject areas

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