TY - JOUR
T1 - Posttransplant diabetes mellitus in liver transplant recipients
AU - Driscoll, Carolyn
AU - Cashion, Ann
AU - Hathaway, Donna
AU - Thompson, Carol
AU - Conley, Yvette
AU - Gaber, Osama
AU - Vera, Santiago
AU - Shokouh-Amiri, Hosein
PY - 2006/6/1
Y1 - 2006/6/1
N2 - Context-Approximately 20% of liver transplant recipients develop posttransplant diabetes mellitus. Hepatitis C, a leading indication for liver transplantation, has been identified as a risk factor for posttransplant diabetes mellitus and is an observation that is not well described.Objective-To evaluate the incidence of posttransplant diabetes mellitus and risk factors associated with this condition.Design-A retrospective chart review.Setting-A large urban transplant center.Patients-One hundred fifteen liver transplant recipients who received a transplant between January 1, 1998, and August 31, 2001.Results-The rate of posttransplant diabetes mellitus, calculated at 3-month intervals in the first year after liver transplantation, ranged from 19.4% to 24.6%, which is similar to the averages reported in most published studies. The cumulative rate of posttransplant diabetes mellitus, which includes all patients who developed this condition during the time studied, was 31.3%. Clinical and demographic factors, including immunosuppression regimens, were similar between patients with and without posttransplant diabetes mellitus. Two risk factors for posttransplant diabetes mellitus were identified: hepatitis C, which was the leading indication for transplantation in this group (54.8%), and cytomegalovirus infection during the first year after transplantation. Other clinical and demographic variables, such as gender, age, ethnicity, rejection episodes, body mass index, and immunosuppression, were not identified as risk factors for posttransplant diabetes mellitus in liver transplant recipients.
AB - Context-Approximately 20% of liver transplant recipients develop posttransplant diabetes mellitus. Hepatitis C, a leading indication for liver transplantation, has been identified as a risk factor for posttransplant diabetes mellitus and is an observation that is not well described.Objective-To evaluate the incidence of posttransplant diabetes mellitus and risk factors associated with this condition.Design-A retrospective chart review.Setting-A large urban transplant center.Patients-One hundred fifteen liver transplant recipients who received a transplant between January 1, 1998, and August 31, 2001.Results-The rate of posttransplant diabetes mellitus, calculated at 3-month intervals in the first year after liver transplantation, ranged from 19.4% to 24.6%, which is similar to the averages reported in most published studies. The cumulative rate of posttransplant diabetes mellitus, which includes all patients who developed this condition during the time studied, was 31.3%. Clinical and demographic factors, including immunosuppression regimens, were similar between patients with and without posttransplant diabetes mellitus. Two risk factors for posttransplant diabetes mellitus were identified: hepatitis C, which was the leading indication for transplantation in this group (54.8%), and cytomegalovirus infection during the first year after transplantation. Other clinical and demographic variables, such as gender, age, ethnicity, rejection episodes, body mass index, and immunosuppression, were not identified as risk factors for posttransplant diabetes mellitus in liver transplant recipients.
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U2 - 10.1177/152692480601600204
DO - 10.1177/152692480601600204
M3 - Review article
C2 - 16789699
AN - SCOPUS:33746715707
VL - 16
SP - 110
EP - 116
JO - Progress in Transplantation
JF - Progress in Transplantation
SN - 1526-9248
IS - 2
ER -