Postprandial effects on arterial stiffness parameters in healthy young adults

Tyler Murray, Eric Y. Yang, Gerd Brunner, Anirudh Kumar, Nasser Lakkis, Arunima Misra, Salim S. Virani, Craig J. Hartley, Joel D. Morrisett, Christie M. Ballantyne, Vijay Nambi

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Postprandial lipemia has been associated with acute endothelial dysfunction. Endothelial dysfunction, in turn, is associated with increased arterial stiffness. However, the relationship between postprandial lipemia and acute changes in arterial stiffness has not been extensively investigated. Therefore, we conducted a pilot study on the effects of postprandial lipemia on arterial stiffness in 19 healthy young adults before and after consumption of a high-fat mixed meal. Arterial stiffness was assessed locally with echo-tracking carotid arterial strain (CAS) and globally with carotid-femoral pulse wave velocity (PWV). As assessed by these two benchmark parameters, arterial stiffness did not differ significantly postprandially. However, the arterial distension period (ADP) was significantly lower 2 hours after mixed meal ingestion. In addition, slopes of carotid artery area (CAA) curves were significantly steeper postprandially. Therefore, we concluded that ADP may be a more sensitive marker of arterial stiffness in healthy young adults when compared to PWV and CAS.

Original languageEnglish (US)
Pages (from-to)501-508
Number of pages8
JournalVascular Medicine (United Kingdom)
Issue number6
StatePublished - Dec 1 2015


  • Arterial distension period
  • arterial stiffness
  • postprandial lipemia
  • pulse wave velocity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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