帕金森病患者尸检迷走神经病理和肠道神经炎症分析

Translated title of the contribution: Postmortem analysis of vagus nerve pathology and intestinal neuroinflammation in Parkinson’s disease

Zhaofei Yang, Lei Sun, Daqing Kou, Tianbai Li, Zhigang Sun, Weidong Le

Research output: Contribution to journalArticle

Abstract

Objective: To investigate the roles of neuroinflammation and pathology of peripheral nervous system in the pathogenesis of Parkinson’s disease (PD). Methods: Immunohistochemical staining was performed to examine the nodose ganglia (containing vagus nerve) and intestine of an autopsy case of PD. The neuroinflammation and morphological changes of vagus nerve and enteric nervous system were observed. Results: The expressions and distributions of glial fibrillary acidic protein and ionized calcium binding adapter molecule 1, two typical glia cell biomarkers, were different in vagus nerve and intestinal mucosa. Tumor necrosis factor α and inducible nitric oxide synthase were expressed in intestinal mucosa and myenteric plexus of the PD patient. There was a strong inflammatory reaction in the myenteric plexus, which distributed diffusely. Conclusion: Satellite glial cells and intestinal inflammatory response may play a role in the pathogenesis of PD.

Translated title of the contributionPostmortem analysis of vagus nerve pathology and intestinal neuroinflammation in Parkinson’s disease
Original languageChinese
Pages (from-to)387-393
Number of pages7
JournalChinese Journal of Neurology
Volume52
Issue number5
DOIs
StatePublished - May 8 2019

Keywords

  • Enteric glial cells
  • Neuroinflammation
  • Parkinson disease
  • Vagus nerve

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Postmortem analysis of vagus nerve pathology and intestinal neuroinflammation in Parkinson’s disease'. Together they form a unique fingerprint.

Cite this