Posterior cranial fossa gangliogliomas

Sam Safavi-Abbasi, Federico Di Rocco, Kraisri Chantra, Guenther C. Feigl, Amr El-Shawarby, Amir Samii, Madjid Samii

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Ganglioglioma (GG) is an uncommon primary lesion of the central nervous system that is typically located supratentorially. There are only a few reports of GG arising from the cerebellum. To the best of our knowledge this is the first case of a cerebellar GG with supratentorial extension and a longstanding history before its recognition. In fact, this 29-year-old male presented with an 11-year history of intermittent headaches. A cranial computerized tomography (CT) performed at the onset of his complaints failed to reveal the tumor. After a particularly longstanding cephalalgic episode, the patient underwent a new CT scan that was also negative. However, magnetic resonance (MR) imaging of the brain revealed a space-occupying lesion in the right cerebellar hemisphere with extension to the level of the superior colliculi and pineal recess. The tumor was partially removed through a midline suboccipital craniotomy and supracerebellar approach. Pathological examination of the tumor showed composition of atypical ganglion cells and astrocytes, indicating the diagnosis of cerebellar GG. At last follow-up, 24 months after surgery, the patient reported a marked improvement of his clinical condition with significant reduction of intensity and frequency of the headache. The present report illustrates how cerebellar GG may remain undetectable by CT and may therefore present with a longstanding history and nonspecific signs and symptoms. MR investigation can lead to the proper diagnosis. Even after partial removal the prognosis remains good and remission of the symptoms may be achieved. In this article, we review the literature and summarize the current understanding of infratentorial GGs.

Original languageEnglish (US)
Pages (from-to)253-263
Number of pages11
JournalSkull Base
Issue number4
StatePublished - Jul 2007


  • Brainstem
  • Cerebellum
  • Ganglioglioma
  • History
  • Neuronal tumors
  • Posterior cranial fossa

ASJC Scopus subject areas

  • Clinical Neurology


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