TY - JOUR
T1 - Possible role of cholinesterase inhibitors on memory consolidation following hypobaric hypoxia of rats
AU - Muthuraju, Sangu
AU - Maiti, Panchanan
AU - Solanki, Preeti
AU - Sharma, Alpesh Kumar
AU - Pati, Soumya
AU - Singh, Shashi Bala
AU - Prasad, Dipti
AU - Ilavazhagan, Govindasamy
N1 - Funding Information:
1Neurobiology Division, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Ministry of Defence, Government of India, Delhi, India 2Defence Institute of High Altitude Research, Defence Research and Development Organization, Ministry of Defence, Government of India, Delhi, India 3Department of Neuroscience, School of Medical Sciences, University Sains Malaysia, Kubang Kerian, Kota Bharu, Malaysia
Funding Information:
Address correspondence to Dr. Govindasamy Ilavazhagan, Director, Neurobiology Division, Defence Institute of Physiology and Allied Sciences, Defence Research and Development Organization, Ministry of Defence, Government of India, Lucknow Road, Timarpur, Delhi-110054, India. E-mail: [email protected]
PY - 2011/5
Y1 - 2011/5
N2 - High altitude (HA) generates a deleterious effect known as hypobaric hypoxia (HBH). This causes severe physiological and psychological changes such as acute mountain sickness (AMS) and cognitive functions in terms of learning and memory. The present study has evaluated the effect of cholinesterase inhibitors on memory consolidation following HBH. Adult male Sprague Dawley rats (80-90 days old) with an average body weight of 250 ± 25 g were used. Rats were assessed memory consolidation by using Morris water maze (MWM) for 8 days. After assessment of memory consolidation, rats were then exposed to HBH in stimulated chamber for 7 days at 6,100 m. After exposure to HBH, the memory consolidation of rats has been assessed in MWM. The results showed that there was memory consolidation impairment in HBH-exposed rats as compared to normoxic rats in terms of time spent in quaradents, rings, and counters. The rats which have been treated with physostigmine (PHY) and galantamine (GAL) showed better time spent in quaradents, rings, and counters as compared with hypoxic rats. In conclusion, the cholinesterase inhibitors could ameliorate the impairment of memory consolidation following HBH.
AB - High altitude (HA) generates a deleterious effect known as hypobaric hypoxia (HBH). This causes severe physiological and psychological changes such as acute mountain sickness (AMS) and cognitive functions in terms of learning and memory. The present study has evaluated the effect of cholinesterase inhibitors on memory consolidation following HBH. Adult male Sprague Dawley rats (80-90 days old) with an average body weight of 250 ± 25 g were used. Rats were assessed memory consolidation by using Morris water maze (MWM) for 8 days. After assessment of memory consolidation, rats were then exposed to HBH in stimulated chamber for 7 days at 6,100 m. After exposure to HBH, the memory consolidation of rats has been assessed in MWM. The results showed that there was memory consolidation impairment in HBH-exposed rats as compared to normoxic rats in terms of time spent in quaradents, rings, and counters. The rats which have been treated with physostigmine (PHY) and galantamine (GAL) showed better time spent in quaradents, rings, and counters as compared with hypoxic rats. In conclusion, the cholinesterase inhibitors could ameliorate the impairment of memory consolidation following HBH.
KW - Cholinesterase inhibitors
KW - Morris water maze
KW - hypobaric hypoxia
KW - memory consolidation
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U2 - 10.3109/00207454.2011.556279
DO - 10.3109/00207454.2011.556279
M3 - Article
C2 - 21348795
AN - SCOPUS:79955833974
SN - 0020-7454
VL - 121
SP - 279
EP - 288
JO - International Journal of Neuroscience
JF - International Journal of Neuroscience
IS - 5
ER -