Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice

Zhongqiu Zhang, Manabu Futamura, Haris G. Vikis, Min Wang, Jie Li, Yian Wang, Kun Liang Guan, Ming You

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Pulmonary adenoma susceptibility 1 (Pas1), located on chromosome 6, is the major locus affecting inherited predisposition to lung tumor development in mice. We have fine mapped the Pas1 locus to a region of ≈0.5 megabases by using congenic strains of mice, constructed by placing the Pas1 region of chromosome 6 from A/J mice onto the genetic background of C57BL/6J mice. Systematic characterization of Pas1 candidates establishes the Las1 (lung adenoma susceptibility 1) and Kras2 (Kirsten rat sarcoma oncogene 2) genes as primary candidates for the Pas1 locus. Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity.

Original languageEnglish (US)
Pages (from-to)12642-12647
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number22
DOIs
StatePublished - Oct 28 2003

ASJC Scopus subject areas

  • General

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