Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice

Zhongqiu Zhang; Manabu Futamura; Haris G. Vikis; Min Wang; Jie Li; Yian Wang; Kun Liang Guan; Ming You

doi:10.1073/pnas.2133947100

Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice

Zhongqiu Zhang, Manabu Futamura, Haris G. Vikis, Min Wang, Jie Li, Yian Wang, Kun Liang Guan, Ming You

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Abstract

Pulmonary adenoma susceptibility 1 (Pas1), located on chromosome 6, is the major locus affecting inherited predisposition to lung tumor development in mice. We have fine mapped the Pas1 locus to a region of ≈0.5 megabases by using congenic strains of mice, constructed by placing the Pas1 region of chromosome 6 from A/J mice onto the genetic background of C57BL/6J mice. Systematic characterization of Pas1 candidates establishes the Las1 (lung adenoma susceptibility 1) and Kras2 (Kirsten rat sarcoma oncogene 2) genes as primary candidates for the Pas1 locus. Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity.

Original language	English (US)
Pages (from-to)	12642-12647
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	100
Issue number	22
DOIs	https://doi.org/10.1073/pnas.2133947100
State	Published - Oct 28 2003

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title = "Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice",

abstract = "Pulmonary adenoma susceptibility 1 (Pas1), located on chromosome 6, is the major locus affecting inherited predisposition to lung tumor development in mice. We have fine mapped the Pas1 locus to a region of ≈0.5 megabases by using congenic strains of mice, constructed by placing the Pas1 region of chromosome 6 from A/J mice onto the genetic background of C57BL/6J mice. Systematic characterization of Pas1 candidates establishes the Las1 (lung adenoma susceptibility 1) and Kras2 (Kirsten rat sarcoma oncogene 2) genes as primary candidates for the Pas1 locus. Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity.",

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T1 - Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice

AU - Zhang, Zhongqiu

AU - Futamura, Manabu

AU - Vikis, Haris G.

AU - Wang, Min

AU - Li, Jie

AU - Wang, Yian

AU - Guan, Kun Liang

AU - You, Ming

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AB - Pulmonary adenoma susceptibility 1 (Pas1), located on chromosome 6, is the major locus affecting inherited predisposition to lung tumor development in mice. We have fine mapped the Pas1 locus to a region of ≈0.5 megabases by using congenic strains of mice, constructed by placing the Pas1 region of chromosome 6 from A/J mice onto the genetic background of C57BL/6J mice. Systematic characterization of Pas1 candidates establishes the Las1 (lung adenoma susceptibility 1) and Kras2 (Kirsten rat sarcoma oncogene 2) genes as primary candidates for the Pas1 locus. Clearly, Kras2 affects lung tumor progression only, and Las1 is likely to affect lung tumor multiplicity.

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Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice

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