Porous silicon nanoneedles by metal assisted chemical etch for intracellular sensing and delivery

C. Chiappini, E. De Rosa, J. O. Martinez, P. Campagnolo, C. Almeida, E. Tasciotti, M. M. Stevens

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Metal assisted chemical etch has recently come to prominence as a versatile strategy for the realization of silicon nanostructures with tailored porosity. By exploiting metal assisted chemical etch, we recently developed porous silicon nanoneedles capable of interfacing with cells for delivery to and sensing of the intracellular milieu. Here we review our recently published studies on the fabrication of such nanostructures. Further we review their use as vectors for the localized delivery nucleic acids capable of inducing neovasculature formation in a mouse model. Finally we provide an overview of our findings on the use of porous silicon nanoneedles as intracellular sensors for detection of enzymatic activity with high resolution across excised human tissue samples.

Original languageEnglish (US)
Title of host publicationPits and Pores 6
Subtitle of host publicationNanomaterials - In Memory of Yukio H. Ogata
EditorsR. Boukherroub, D. J. Lockwood, H. Masuda, P. Granitzer
PublisherElectrochemical Society Inc.
Pages63-68
Number of pages6
Edition2
ISBN (Electronic)9781607685395
DOIs
StatePublished - 2015
EventSymposium on Pits and Pores 6: Nanomaterials - In Memory of Yukio H. Ogata - 228th ECS Meeting - Phoenix, United States
Duration: Oct 11 2015Oct 15 2015

Publication series

NameECS Transactions
Number2
Volume69
ISSN (Print)1938-5862
ISSN (Electronic)1938-6737

Other

OtherSymposium on Pits and Pores 6: Nanomaterials - In Memory of Yukio H. Ogata - 228th ECS Meeting
CountryUnited States
CityPhoenix
Period10/11/1510/15/15

ASJC Scopus subject areas

  • Engineering(all)

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