Porous silicon advances in drug delivery and immunotherapy

David J. Savage, Xuewu Liu, Steven A. Curley, Mauro Ferrari, Rita E. Serda

Research output: Contribution to journalReview article

48 Scopus citations

Abstract

Biomedical applications of porous silicon include drug delivery, imaging, diagnostics and immunotherapy. This review summarizes new silicon particle fabrication techniques, dynamics of cellular transport, advances in the multistage vector approach to drug delivery, and the use of porous silicon as immune adjuvants. Recent findings support superior therapeutic efficacy of the multistage vector approach over single particle drug delivery systems in mouse models of ovarian and breast cancer. With respect to vaccine development, multivalent presentation of pathogen-associated molecular patterns on the particle surface creates powerful platforms for immunotherapy, with the porous matrix able to carry both antigens and immune modulators.

Original languageEnglish (US)
Pages (from-to)834-841
Number of pages8
JournalCurrent Opinion in Pharmacology
Volume13
Issue number5
DOIs
StatePublished - Oct 2013

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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