Porous phosphate-gelatine composite as bone graft with drug delivery function

A. Tampieri; G. Celotti; E. Landi; M. Montevecchi; N. Roveri; A. Bigi; S. Panzavolta; M. C. Sidoti

doi:10.1023/A:1024027125003

Porous phosphate-gelatine composite as bone graft with drug delivery function

A. Tampieri, G. Celotti, E. Landi, M. Montevecchi, N. Roveri, A. Bigi, S. Panzavolta, M. C. Sidoti

Houston Methodist

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The design and synthesis of porous phosphate-gelatine composite implant which mimicks the structure of natural bone and has drug delivery function is proposed. Gelatine reproducing the proteinaceous part of bone was cross-linked in order to modulate its solubility in the physiologic fluids. The kinetic of gelatine release from ceramic matrix was also evaluated as model of the release of any therapeutic compound which can be loaded into gelatine.

Original language	English (US)
Pages (from-to)	623-627
Number of pages	5
Journal	Journal of Materials Science: Materials in Medicine
Volume	14
Issue number	7
DOIs	https://doi.org/10.1023/A:1024027125003
State	Published - Jul 1 2003

ASJC Scopus subject areas

Biophysics
Bioengineering
Biomaterials
Biomedical Engineering

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AU - Celotti, G.

AU - Landi, E.

AU - Montevecchi, M.

AU - Roveri, N.

AU - Bigi, A.

AU - Panzavolta, S.

AU - Sidoti, M. C.

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N2 - The design and synthesis of porous phosphate-gelatine composite implant which mimicks the structure of natural bone and has drug delivery function is proposed. Gelatine reproducing the proteinaceous part of bone was cross-linked in order to modulate its solubility in the physiologic fluids. The kinetic of gelatine release from ceramic matrix was also evaluated as model of the release of any therapeutic compound which can be loaded into gelatine.

AB - The design and synthesis of porous phosphate-gelatine composite implant which mimicks the structure of natural bone and has drug delivery function is proposed. Gelatine reproducing the proteinaceous part of bone was cross-linked in order to modulate its solubility in the physiologic fluids. The kinetic of gelatine release from ceramic matrix was also evaluated as model of the release of any therapeutic compound which can be loaded into gelatine.

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Porous phosphate-gelatine composite as bone graft with drug delivery function

Abstract

ASJC Scopus subject areas

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