Porosity-graded hydroxyapatite ceramics to replace natural bone

Anna Tampieri, G. Celotti, S. Sprio, A. Delcogliano, S. Franzese

Research output: Contribution to journalArticle

253 Scopus citations

Abstract

Porous hydroxyapatite HA bodies were prepared with an aim to simulate bone tissue morphology. By varying the characteristics of starting HA powders and the impregnation strategy of cellulosic sponges with rheologically optimized slurries, a wide range of physico-chemical and mechanical properties of the porous ceramics can be obtained. The samples were characterized microstructurally, by density and porosimetry and by mechanical strength. Cylindrical specimens exhibiting a porosity gradient showed a promising behaviour after implantation in rabbits' femur: newly formed bone grew in tight contact with the ceramic in a very short time, no modified cells are induced and bone tissue fills even the inner pores.

Original languageEnglish (US)
Pages (from-to)1365-1370
Number of pages6
JournalBiomaterials
Volume22
Issue number11
DOIs
StatePublished - Jun 1 2001

Keywords

  • Bone tissue mimicking
  • Hydroxyapatite
  • Porosity gradient
  • Porous ceramic

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Porosity-graded hydroxyapatite ceramics to replace natural bone'. Together they form a unique fingerprint.

Cite this