Porosity-graded hydroxyapatite ceramics to replace natural bone

A. Tampieri; G. Celotti; S. Sprio; A. Delcogliano; S. Franzese

doi:10.1016/S0142-9612(00)00290-8

Porosity-graded hydroxyapatite ceramics to replace natural bone

A. Tampieri, G. Celotti, S. Sprio, A. Delcogliano, S. Franzese

Research output: Contribution to journal › Article › peer-review

275 Scopus citations

Abstract

Porous hydroxyapatite HA bodies were prepared with an aim to simulate bone tissue morphology. By varying the characteristics of starting HA powders and the impregnation strategy of cellulosic sponges with rheologically optimized slurries, a wide range of physico-chemical and mechanical properties of the porous ceramics can be obtained. The samples were characterized microstructurally, by density and porosimetry and by mechanical strength. Cylindrical specimens exhibiting a porosity gradient showed a promising behaviour after implantation in rabbits' femur: newly formed bone grew in tight contact with the ceramic in a very short time, no modified cells are induced and bone tissue fills even the inner pores.

Original language	English (US)
Pages (from-to)	1365-1370
Number of pages	6
Journal	Biomaterials
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/S0142-9612(00)00290-8
State	Published - Jun 1 2001

Keywords

Bone tissue mimicking
Hydroxyapatite
Porosity gradient
Porous ceramic

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/S0142-9612(00)00290-8

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abstract = "Porous hydroxyapatite HA bodies were prepared with an aim to simulate bone tissue morphology. By varying the characteristics of starting HA powders and the impregnation strategy of cellulosic sponges with rheologically optimized slurries, a wide range of physico-chemical and mechanical properties of the porous ceramics can be obtained. The samples were characterized microstructurally, by density and porosimetry and by mechanical strength. Cylindrical specimens exhibiting a porosity gradient showed a promising behaviour after implantation in rabbits' femur: newly formed bone grew in tight contact with the ceramic in a very short time, no modified cells are induced and bone tissue fills even the inner pores.",

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AU - Tampieri, A.

AU - Celotti, G.

AU - Sprio, S.

AU - Delcogliano, A.

AU - Franzese, S.

PY - 2001/6/1

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AB - Porous hydroxyapatite HA bodies were prepared with an aim to simulate bone tissue morphology. By varying the characteristics of starting HA powders and the impregnation strategy of cellulosic sponges with rheologically optimized slurries, a wide range of physico-chemical and mechanical properties of the porous ceramics can be obtained. The samples were characterized microstructurally, by density and porosimetry and by mechanical strength. Cylindrical specimens exhibiting a porosity gradient showed a promising behaviour after implantation in rabbits' femur: newly formed bone grew in tight contact with the ceramic in a very short time, no modified cells are induced and bone tissue fills even the inner pores.

KW - Bone tissue mimicking

KW - Hydroxyapatite

KW - Porosity gradient

KW - Porous ceramic

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Porosity-graded hydroxyapatite ceramics to replace natural bone

Abstract

Keywords

ASJC Scopus subject areas

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