Pore structures and properties of ice-designed apatite scaffolds for bone substitutions

Federica Valentini, Elena Landi, Domenica Tonelli, Anna Tampieri

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Apatite scaffolds with complex porous macro- and micro-structures have been obtained by controlling the freezing of ceramics slurries and then performing ice sublimation and sintering. Architectures and mechanical properties of hydroxyapatite (HA) and biomimetic Sr-substituted hydroxyapatite (SrHA) scaffolds have been compared, pointing out the influence of the stoichiometry of the apatite on the final features of the synthetic bone substitutes. Biomimetic apatites are per sé systems delivering and releasing in situ ions with specific biological functions (Sr is an anti-osteoporotic ion). An antibiotic release can be associated to this intrinsic delivery function. A high performance liquid chromatography (HPLC) method exploiting an anionic column and a pulsed amperometric detector (PAD) has been developed and validated to follow the tobramycin release from an apatite-based system into a simulated body fluid (SBF).

Original languageEnglish (US)
Title of host publicationA Global Road Map for Ceramic Materials and Technologies
Subtitle of host publicationForecasting the Future of Ceramics, International Ceramic Federation - 2nd International Congress on Ceramics, ICC 2008, Final Programme
StatePublished - Dec 1 2008
Event2nd International Congress on Ceramics, ICC 2008 - Verona, Italy
Duration: Jun 29 2008Jul 4 2008


Other2nd International Congress on Ceramics, ICC 2008

ASJC Scopus subject areas

  • Ceramics and Composites


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