Population-based surveillance of extensively drug-resistant tuberculosis in Shandong Province, China

X. Li; Haiying Wang; H. Jing; Y. Wang; C. Yu; J. Wang; Z. Liu; E. A. Graviss; Xin Ma

doi:10.5588/ijtld.11.0507

Population-based surveillance of extensively drug-resistant tuberculosis in Shandong Province, China

X. Li, Haiying Wang, H. Jing, Y. Wang, C. Yu, J. Wang, Z. Liu, E. A. Graviss, Xin Ma

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

To investigate the prevalence of extensively drug-resistant tuberculosis (XDR-TB) in Chinese populations, we analyzed the drug resistance profiles of 1787 Mycobacterium tuberculosis isolates through a population-based surveillance project in Shandong Province, China. We found 330 (18.5%; 95%CI 16.1-20.3) isolates resistant to ≥1 first-line drug and 65 (3.6%; 95%CI 2.9-4.6) multidrug-resistant (MDR) isolates, of which 13 (20.0%; 95%CI 11.9-31.4) were XDR; 47/65 MDR-TB isolates (70.8%; 95%CI 58.2-81.4) were resistant to fluoroquinolones. Our results indicate that inadequate application of second-line anti-tuberculosis drugs has caused increased prevalence of XDR-TB in certain Chinese populations.

Original language	English (US)
Pages (from-to)	612-614
Number of pages	3
Journal	International Journal of Tuberculosis and Lung Disease
Volume	16
Issue number	5
DOIs	https://doi.org/10.5588/ijtld.11.0507
State	Published - May 1 2012

Keywords

Extensively drug-resistant tuberculosis
Multidrug-resistant tuberculosis
Mycobacterium tuberculosis

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Infectious Diseases

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10.5588/ijtld.11.0507

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title = "Population-based surveillance of extensively drug-resistant tuberculosis in Shandong Province, China",

abstract = "To investigate the prevalence of extensively drug-resistant tuberculosis (XDR-TB) in Chinese populations, we analyzed the drug resistance profiles of 1787 Mycobacterium tuberculosis isolates through a population-based surveillance project in Shandong Province, China. We found 330 (18.5%; 95%CI 16.1-20.3) isolates resistant to ≥1 first-line drug and 65 (3.6%; 95%CI 2.9-4.6) multidrug-resistant (MDR) isolates, of which 13 (20.0%; 95%CI 11.9-31.4) were XDR; 47/65 MDR-TB isolates (70.8%; 95%CI 58.2-81.4) were resistant to fluoroquinolones. Our results indicate that inadequate application of second-line anti-tuberculosis drugs has caused increased prevalence of XDR-TB in certain Chinese populations.",

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author = "X. Li and Haiying Wang and H. Jing and Y. Wang and C. Yu and J. Wang and Z. Liu and Graviss, {E. A.} and Xin Ma",

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AU - Li, X.

AU - Wang, Haiying

AU - Jing, H.

AU - Wang, Y.

AU - Yu, C.

AU - Wang, J.

AU - Liu, Z.

AU - Graviss, E. A.

AU - Ma, Xin

PY - 2012/5/1

Y1 - 2012/5/1

N2 - To investigate the prevalence of extensively drug-resistant tuberculosis (XDR-TB) in Chinese populations, we analyzed the drug resistance profiles of 1787 Mycobacterium tuberculosis isolates through a population-based surveillance project in Shandong Province, China. We found 330 (18.5%; 95%CI 16.1-20.3) isolates resistant to ≥1 first-line drug and 65 (3.6%; 95%CI 2.9-4.6) multidrug-resistant (MDR) isolates, of which 13 (20.0%; 95%CI 11.9-31.4) were XDR; 47/65 MDR-TB isolates (70.8%; 95%CI 58.2-81.4) were resistant to fluoroquinolones. Our results indicate that inadequate application of second-line anti-tuberculosis drugs has caused increased prevalence of XDR-TB in certain Chinese populations.

AB - To investigate the prevalence of extensively drug-resistant tuberculosis (XDR-TB) in Chinese populations, we analyzed the drug resistance profiles of 1787 Mycobacterium tuberculosis isolates through a population-based surveillance project in Shandong Province, China. We found 330 (18.5%; 95%CI 16.1-20.3) isolates resistant to ≥1 first-line drug and 65 (3.6%; 95%CI 2.9-4.6) multidrug-resistant (MDR) isolates, of which 13 (20.0%; 95%CI 11.9-31.4) were XDR; 47/65 MDR-TB isolates (70.8%; 95%CI 58.2-81.4) were resistant to fluoroquinolones. Our results indicate that inadequate application of second-line anti-tuberculosis drugs has caused increased prevalence of XDR-TB in certain Chinese populations.

KW - Extensively drug-resistant tuberculosis

KW - Multidrug-resistant tuberculosis

KW - Mycobacterium tuberculosis

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Population-based surveillance of extensively drug-resistant tuberculosis in Shandong Province, China

Abstract

Keywords

ASJC Scopus subject areas

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