Population-based surveillance of extensively drug-resistant tuberculosis in Shandong Province, China

X. Li, Haiying Wang, H. Jing, Y. Wang, C. Yu, J. Wang, Z. Liu, E. A. Graviss, Xin Ma

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

To investigate the prevalence of extensively drug-resistant tuberculosis (XDR-TB) in Chinese populations, we analyzed the drug resistance profiles of 1787 Mycobacterium tuberculosis isolates through a population-based surveillance project in Shandong Province, China. We found 330 (18.5%; 95%CI 16.1-20.3) isolates resistant to ≥1 first-line drug and 65 (3.6%; 95%CI 2.9-4.6) multidrug-resistant (MDR) isolates, of which 13 (20.0%; 95%CI 11.9-31.4) were XDR; 47/65 MDR-TB isolates (70.8%; 95%CI 58.2-81.4) were resistant to fluoroquinolones. Our results indicate that inadequate application of second-line anti-tuberculosis drugs has caused increased prevalence of XDR-TB in certain Chinese populations.

Original languageEnglish (US)
Pages (from-to)612-614
Number of pages3
JournalInternational Journal of Tuberculosis and Lung Disease
Volume16
Issue number5
DOIs
StatePublished - May 1 2012

Keywords

  • Extensively drug-resistant tuberculosis
  • Multidrug-resistant tuberculosis
  • Mycobacterium tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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