Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast

A. C. Chen, A. C. Paulino, M. R. Schwartz, Angel Augusto Rodriguez, Barbara L. Bass, Jenny C. Chang, Bin S. Teh

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Background: Invasive micropapillary carcinoma (IMPC) is a variant of breast carcinoma with a higher propensity for lymph node metastases compared with invasive ductal carcinoma (IDC).Methods:Retrospective analysis of 636 IMPC and 297 735 IDC cases in the Surveillance, Epidemiology and End Results database comparing disease-specific survival (DSS) and overall survival (OS) between IMPC and IDC.Results:A higher percentage of IMPC cases (52.0%) had nodal metastases compared with IDC cases (34.6%). The 5-year DSS and OS for IMPC was 91.8% and 82.9%, respectively compared with 88.6% and 80.5% for IDC, respectively. For both IMPC and IDC, oestrogen-receptor positivity was associated with better survival, while having four or more positive lymph nodes or larger tumour size correlated with worse survival. Radiotherapy provided a survival benefit for both histological types.Conclusions:Despite IMPC's higher propensity for lymph node metastasis, IMPC has DSS and OS that compare favourably with IDC.

Original languageEnglish (US)
Pages (from-to)619-622
Number of pages4
JournalBritish Journal of Cancer
Volume111
Issue number3
DOIs
StatePublished - Jul 29 2014

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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