Polypyrimidine tract-binding protein down-regulates fibroblast growth factor receptor 1 α-exon inclusion

Wei Jin, Ivone G. Bruno, Tong Xin Xie, Laura J. Sanger, Gilbert J. Cote

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Exclusion of the α-exon by alternative RNA splicing of the fibroblast growth factor receptor 1 (FGFR1) primary transcript leads to the production of FGFR1β. Glial cell transformation is associated with a progressive increase in FGFR1β expression that coincides with a dramatic increase in the expression of the splicing factor polypyrimidine tract-binding protein (PTB). Cell-specific overexpression of PTB increased α-exon skipping, and a reduction in PTB increased α-exon inclusion. Targeted disruption of PTB interaction with FGFR1 precursor RNA in vivo by an antisense oligonucleotide also increased α-exon inclusion. These results suggest that PTB plays a direct role in α-exon splicing.

Original languageEnglish (US)
Pages (from-to)6154-6157
Number of pages4
JournalCancer research
Volume63
Issue number19
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Polypyrimidine tract-binding protein down-regulates fibroblast growth factor receptor 1 α-exon inclusion'. Together they form a unique fingerprint.

Cite this