Polymorphism of NACP-Rep1 in Parkinson's disease: An etiologic link with essential tremor?

E. K. Tan; T. Matsuura; S. Nagamitsu; M. Khajavi; J. Jankovic; Tetsuo Ashizawa

doi:10.1212/WNL.54.5.1195

Polymorphism of NACP-Rep1 in Parkinson's disease: An etiologic link with essential tremor?

E. K. Tan, T. Matsuura, S. Nagamitsu, M. Khajavi, J. Jankovic, Tetsuo Ashizawa

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

An allele (263bp) of the nonamyloid component of plaques (NACP)-Rep1 polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.

Original language	English (US)
Pages (from-to)	1195-1198
Number of pages	4
Journal	Neurology
Volume	54
Issue number	5
DOIs	https://doi.org/10.1212/WNL.54.5.1195
State	Published - Mar 14 2000

Keywords

Essential tremor
NACP
PD
Polymorphism
Rep1

ASJC Scopus subject areas

Clinical Neurology

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10.1212/WNL.54.5.1195

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title = "Polymorphism of NACP-Rep1 in Parkinson's disease: An etiologic link with essential tremor?",

abstract = "An allele (263bp) of the nonamyloid component of plaques (NACP)-Rep1 polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.",

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AU - Tan, E. K.

AU - Matsuura, T.

AU - Nagamitsu, S.

AU - Khajavi, M.

AU - Jankovic, J.

AU - Ashizawa, Tetsuo

PY - 2000/3/14

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AB - An allele (263bp) of the nonamyloid component of plaques (NACP)-Rep1 polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.

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KW - PD

KW - Polymorphism

KW - Rep1

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Polymorphism of NACP-Rep1 in Parkinson's disease: An etiologic link with essential tremor?

Abstract

Keywords

ASJC Scopus subject areas

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