Polymorphism of NACP-Rep1 in Parkinson's disease: An etiologic link with essential tremor?

E. K. Tan, T. Matsuura, S. Nagamitsu, M. Khajavi, J. Jankovic, Tetsuo Ashizawa

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

An allele (263bp) of the nonamyloid component of plaques (NACP)-Rep1 polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.

Original languageEnglish (US)
Pages (from-to)1195-1198
Number of pages4
JournalNeurology
Volume54
Issue number5
DOIs
StatePublished - Mar 14 2000

Keywords

  • Essential tremor
  • NACP
  • PD
  • Polymorphism
  • Rep1

ASJC Scopus subject areas

  • Clinical Neurology

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