Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females

Jian Zhao; Dong Hai Xiong; Yan Guo; Tie Lin Yang; Robert R. Recker; Hong Wen Deng

doi:10.1093/humrep/dem052

Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females

Jian Zhao, Dong Hai Xiong, Yan Guo, Tie Lin Yang, Robert R. Recker, Hong Wen Deng

Academic Institute

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Background: The insulin-like growth factor 1 (IGF1) gene, which plays a crucial role in hypothalamic-pituitary-ovarian hormone-controlled metabolic processes, may influence the onset of menarche. Our study aimed to test association between IGF1 polymorphisms with the variation of age at menarche (AAM) in Caucasian females. Methods: We recruited a sample of 1048 females from 354 Caucasian nuclear families and genotyped 19 single-nucleotide polymorphisms (SNPs) spanning the entire IGF1 gene. Pairwise linkage disequilibrium among SNPs was measured, and the haplotype blocks were inferred. Both single SNP markers and haplotypes were tested for association with AAM using the quantitative transmission disequilibrium test. Results: Significantassociation (P = 0.0153) between AAM and SNP3 (rs6214) in block1 was detected. Conclusions: Our results suggested a potential effect of SNP3 in the IGF1 gene on AAM variation in Caucasian women for the first time. However, further independent studies are needed to confirm our findings.

Original language	English (US)
Pages (from-to)	1789-1794
Number of pages	6
Journal	Human Reproduction
Volume	22
Issue number	6
DOIs	https://doi.org/10.1093/humrep/dem052
State	Published - Jun 2007

Keywords

Age at menarche
Association
Haplotype
Insulin-like growth factor 1

ASJC Scopus subject areas

Reproductive Medicine
Obstetrics and Gynecology

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10.1093/humrep/dem052

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@article{4208dc3796444dd497baa3d3f9f24270,

title = "Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females",

abstract = "Background: The insulin-like growth factor 1 (IGF1) gene, which plays a crucial role in hypothalamic-pituitary-ovarian hormone-controlled metabolic processes, may influence the onset of menarche. Our study aimed to test association between IGF1 polymorphisms with the variation of age at menarche (AAM) in Caucasian females. Methods: We recruited a sample of 1048 females from 354 Caucasian nuclear families and genotyped 19 single-nucleotide polymorphisms (SNPs) spanning the entire IGF1 gene. Pairwise linkage disequilibrium among SNPs was measured, and the haplotype blocks were inferred. Both single SNP markers and haplotypes were tested for association with AAM using the quantitative transmission disequilibrium test. Results: Significantassociation (P = 0.0153) between AAM and SNP3 (rs6214) in block1 was detected. Conclusions: Our results suggested a potential effect of SNP3 in the IGF1 gene on AAM variation in Caucasian women for the first time. However, further independent studies are needed to confirm our findings.",

keywords = "Age at menarche, Association, Haplotype, Insulin-like growth factor 1",

author = "Jian Zhao and Xiong, {Dong Hai} and Yan Guo and Yang, {Tie Lin} and Recker, {Robert R.} and Deng, {Hong Wen}",

note = "Funding Information: Investigators of this work were partially supported by grants from NIH (R01 AR050496, K01 AR02170-01, R01 AR45349-01, and R01 GM60402-01A1) and an LB595 grant from the State of Nebraska. The study also benefited from grants from Project 30570875 supported by National Natural Science Foundation of China, Xi{\textquoteright}an Jiaotong University, and the Ministry of Education of China.",

year = "2007",

month = jun,

doi = "10.1093/humrep/dem052",

language = "English (US)",

volume = "22",

pages = "1789--1794",

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issn = "0268-1161",

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T1 - Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females

AU - Zhao, Jian

AU - Xiong, Dong Hai

AU - Guo, Yan

AU - Yang, Tie Lin

AU - Recker, Robert R.

AU - Deng, Hong Wen

N1 - Funding Information: Investigators of this work were partially supported by grants from NIH (R01 AR050496, K01 AR02170-01, R01 AR45349-01, and R01 GM60402-01A1) and an LB595 grant from the State of Nebraska. The study also benefited from grants from Project 30570875 supported by National Natural Science Foundation of China, Xi’an Jiaotong University, and the Ministry of Education of China.

PY - 2007/6

Y1 - 2007/6

N2 - Background: The insulin-like growth factor 1 (IGF1) gene, which plays a crucial role in hypothalamic-pituitary-ovarian hormone-controlled metabolic processes, may influence the onset of menarche. Our study aimed to test association between IGF1 polymorphisms with the variation of age at menarche (AAM) in Caucasian females. Methods: We recruited a sample of 1048 females from 354 Caucasian nuclear families and genotyped 19 single-nucleotide polymorphisms (SNPs) spanning the entire IGF1 gene. Pairwise linkage disequilibrium among SNPs was measured, and the haplotype blocks were inferred. Both single SNP markers and haplotypes were tested for association with AAM using the quantitative transmission disequilibrium test. Results: Significantassociation (P = 0.0153) between AAM and SNP3 (rs6214) in block1 was detected. Conclusions: Our results suggested a potential effect of SNP3 in the IGF1 gene on AAM variation in Caucasian women for the first time. However, further independent studies are needed to confirm our findings.

AB - Background: The insulin-like growth factor 1 (IGF1) gene, which plays a crucial role in hypothalamic-pituitary-ovarian hormone-controlled metabolic processes, may influence the onset of menarche. Our study aimed to test association between IGF1 polymorphisms with the variation of age at menarche (AAM) in Caucasian females. Methods: We recruited a sample of 1048 females from 354 Caucasian nuclear families and genotyped 19 single-nucleotide polymorphisms (SNPs) spanning the entire IGF1 gene. Pairwise linkage disequilibrium among SNPs was measured, and the haplotype blocks were inferred. Both single SNP markers and haplotypes were tested for association with AAM using the quantitative transmission disequilibrium test. Results: Significantassociation (P = 0.0153) between AAM and SNP3 (rs6214) in block1 was detected. Conclusions: Our results suggested a potential effect of SNP3 in the IGF1 gene on AAM variation in Caucasian women for the first time. However, further independent studies are needed to confirm our findings.

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Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in caucasian females

Abstract

Keywords

ASJC Scopus subject areas

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