Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans

Katherine Y. King; Justin D. Lew; Ngan P. Ha; Jeffery S. Lin; Xin Ma; Edward A. Graviss; Margaret A. Goodell

doi:10.1371/journal.pone.0016317

Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans

Katherine Y. King, Justin D. Lew, Ngan P. Ha, Jeffery S. Lin, Xin Ma, Edward A. Graviss, Margaret A. Goodell

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Abstract

An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.

Original language	English (US)
Article number	e16317
Journal	PLoS ONE
Volume	6
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0016317
State	Published - 2011

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences
General

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title = "Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans",

abstract = "An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.",

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AU - King, Katherine Y.

AU - Lew, Justin D.

AU - Ha, Ngan P.

AU - Lin, Jeffery S.

AU - Ma, Xin

AU - Graviss, Edward A.

AU - Goodell, Margaret A.

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AB - An ancestral polymorphic allele of the human autophagy-related gene IRGM1 is associated with altered gene expression and a genetic risk for Crohn's Disease (CD). We used the single nucleotide polymorphism rs10065172C/T as a marker of this polymorphic allele and genotyped 370 African American and 177 Caucasian tuberculosis (TB) cases and 180 African American and 110 Caucasian controls. Among African Americans, the TB cases were more likely to carry the CD-related T allele of rs10065172 (odds ratio of 1.54; 95% confidence interval, 1.17-2.02; P<0.01) compared to controls. Our finding suggests that this CD-related IRGM1 polymorphic allele is also associated with human susceptibility to TB disease among African Americans.

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Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans

Abstract

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