Polymicrobial septicemia in the cancer patient

Linda S. Elting, Gerald P. Bodey, Victor Fainstein

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


The medical records of 507 patients with polymicrobial septicemia were examined to determine prognostic and descriptive factors. Over 50% of the episodes occurred in patients with solid tumors and 80% originated during hospitalization. Invasive procedures and immunosuppressive therapy frequently preceded development of polymicrobial septicemia, and infection was often accompanied by shock and pneumonia. A majority of infections were caused by at least 1 aerobic gram-negative bacillus (76%) and anaerobic infections were not infrequent. Overall response among these patients was 50%, with poorest response seen among patients with persistent neutropenia (25%), pneumonia (19%), and gram-negative bacillary infection (46%). Therapy with an antibiotic regimen to which all causative organisms were sensitive was of greatest prognostic significance. Response to appropriate therapy was 58%, whereas only 10% of those who received inappropriate therapy were cured (p < .0001).

Original languageEnglish (US)
Pages (from-to)218-225
Number of pages8
JournalMedicine (United States)
Issue number4
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Medicine(all)


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