Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

A. Christy Hunter; Jacqueline Elsom; Peter P. Wibroe; S. Moein Moghimi

doi:10.1016/j.maturitas.2012.05.014

Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

A. Christy Hunter, Jacqueline Elsom, Peter P. Wibroe, S. Moein Moghimi

Research Institute

Research output: Contribution to journal › Review article › peer-review

29 Scopus citations

Abstract

The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.

Original language	English (US)
Pages (from-to)	5-18
Number of pages	14
Journal	Maturitas
Volume	73
Issue number	1
DOIs	https://doi.org/10.1016/j.maturitas.2012.05.014
State	Published - Sep 2012

Keywords

Complement
Enterocyte
Gastrointestinal tract
Microparticle
Nanoparticle
Oral drug delivery
Peyers's patch
Polymer

ASJC Scopus subject areas

Obstetrics and Gynecology
Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.maturitas.2012.05.014

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title = "Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective",

abstract = "The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.",

keywords = "Complement, Enterocyte, Gastrointestinal tract, Microparticle, Nanoparticle, Oral drug delivery, Peyers's patch, Polymer",

author = "Hunter, {A. Christy} and Jacqueline Elsom and Wibroe, {Peter P.} and Moghimi, {S. Moein}",

note = "Funding Information: Financial support by the Danish Agency for Science, Technology and Innovation (Det Strategiske Forskningsr{\aa}d) , reference 2106-08-0081 , is gratefully acknowledged by SMM. PPW is a recipient of a PhD Scholarship Award from the Faculty of Health and Medical Sciences, University of Copenhagen. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.",

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AU - Wibroe, Peter P.

AU - Moghimi, S. Moein

N1 - Funding Information: Financial support by the Danish Agency for Science, Technology and Innovation (Det Strategiske Forskningsråd) , reference 2106-08-0081 , is gratefully acknowledged by SMM. PPW is a recipient of a PhD Scholarship Award from the Faculty of Health and Medical Sciences, University of Copenhagen. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.

PY - 2012/9

Y1 - 2012/9

N2 - The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.

AB - The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.

KW - Complement

KW - Enterocyte

KW - Gastrointestinal tract

KW - Microparticle

KW - Nanoparticle

KW - Oral drug delivery

KW - Peyers's patch

KW - Polymer

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Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

Abstract

Keywords

ASJC Scopus subject areas

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