Polymeric particulate technologies for oral drug delivery and targeting: A pathophysiological perspective

A. Christy Hunter, Jacqueline Elsom, Peter P. Wibroe, S. Moein Moghimi

Research output: Contribution to journalReview article

74 Scopus citations

Abstract

The oral route for delivery of pharmaceuticals is the most widely used and accepted. Nanoparticles and microparticles are increasingly being applied within this arena to optimize drug targeting and bioavailability. Frequently the carrier systems used are either constructed from or contain polymeric materials. Examples of these nanocarriers include polymeric nanoparticles, solid lipid nanocarriers, self-nanoemulsifying drug delivery systems and nanocrystals. It is the purpose of this review to describe these cutting edge technologies and specifically focus on the interaction and fate of these polymers within the gastrointestinal system.

Original languageEnglish (US)
Pages (from-to)S5-S20
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume8
Issue numberSUPPL. 1
DOIs
StatePublished - Sep 2012

Keywords

  • Complement
  • Enterocyte
  • Gastrointestinal tract
  • Microparticle
  • Nanoparticle
  • Oral drug delivery
  • Peyers's patch
  • Polymer

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

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