POLYMER-FUNCTIONALIZED MITOCHONDRIAL COMPOSITIONS AND METHODS OF USE IN CELLULAR TRANSPLANTATION AND FOR ALTERING METABOLIC PHENOTYPE

Dale James Hamilton (Inventor), Anisha Anil Gupte (Inventor), Aijun Zhang (Inventor), Elvin Blanco (Inventor)

Research output: Patent

Abstract

Disclosed are methods and compositions including polymer-functionalized mammalian mitochondria, useful in a variety of therapeutic regimens for delivery of desirable genetic traits to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing mitochondria into selected host cells for altering the metabolic phenotype of such host cells using one or more mitochondrially-delivered nucleic acid molecules. The present disclosure is also directed to a method of cellular transplantation, comprising the step of administering to an individual one or more of the polymer functionalized mitochondrial compositions and formulations thereof as described herein.

Original languageEnglish (US)
Patent numberWO2019028469
IPCA61P 35/ 00 A I
Priority date8/4/17
StatePublished - Feb 7 2019

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