POLYMER-FUNCTIONALIZED MITOCHONDRIAL COMPOSITIONS AND METHODS OF USE IN CELLULAR TRANSPLANTATION AND FOR ALTERING METABOLIC PHENOTYPE

Dale James Hamilton; Anisha Anil Gupte; Aijun Zhang; Elvin Blanco

POLYMER-FUNCTIONALIZED MITOCHONDRIAL COMPOSITIONS AND METHODS OF USE IN CELLULAR TRANSPLANTATION AND FOR ALTERING METABOLIC PHENOTYPE

Dale James Hamilton (Inventor), Anisha Anil Gupte (Inventor), Aijun Zhang (Inventor), Elvin Blanco (Inventor)

Houston Methodist The Woodlands Hospital

Research output: Patent

Abstract

Disclosed are methods and compositions including polymer-functionalized mammalian mitochondria, useful in a variety of therapeutic regimens for delivery of desirable genetic traits to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing mitochondria into selected host cells for altering the metabolic phenotype of such host cells using one or more mitochondrially-delivered nucleic acid molecules. The present disclosure is also directed to a method of cellular transplantation, comprising the step of administering to an individual one or more of the polymer functionalized mitochondrial compositions and formulations thereof as described herein.

Original language	English (US)
Patent number	WO2019028469
IPC	A61P 35/ 00 A I
Priority date	8/4/17
State	Published - Feb 7 2019

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title = "POLYMER-FUNCTIONALIZED MITOCHONDRIAL COMPOSITIONS AND METHODS OF USE IN CELLULAR TRANSPLANTATION AND FOR ALTERING METABOLIC PHENOTYPE",

abstract = "Disclosed are methods and compositions including polymer-functionalized mammalian mitochondria, useful in a variety of therapeutic regimens for delivery of desirable genetic traits to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing mitochondria into selected host cells for altering the metabolic phenotype of such host cells using one or more mitochondrially-delivered nucleic acid molecules. The present disclosure is also directed to a method of cellular transplantation, comprising the step of administering to an individual one or more of the polymer functionalized mitochondrial compositions and formulations thereof as described herein.",

author = "Hamilton, {Dale James} and Gupte, {Anisha Anil} and Aijun Zhang and Elvin Blanco",

year = "2019",

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day = "7",

language = "English (US)",

type = "Patent",

note = "WO2019028469; A61P 35/ 00 A I",

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T1 - POLYMER-FUNCTIONALIZED MITOCHONDRIAL COMPOSITIONS AND METHODS OF USE IN CELLULAR TRANSPLANTATION AND FOR ALTERING METABOLIC PHENOTYPE

AU - Hamilton, Dale James

AU - Gupte, Anisha Anil

AU - Zhang, Aijun

AU - Blanco, Elvin

PY - 2019/2/7

Y1 - 2019/2/7

N2 - Disclosed are methods and compositions including polymer-functionalized mammalian mitochondria, useful in a variety of therapeutic regimens for delivery of desirable genetic traits to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing mitochondria into selected host cells for altering the metabolic phenotype of such host cells using one or more mitochondrially-delivered nucleic acid molecules. The present disclosure is also directed to a method of cellular transplantation, comprising the step of administering to an individual one or more of the polymer functionalized mitochondrial compositions and formulations thereof as described herein.

AB - Disclosed are methods and compositions including polymer-functionalized mammalian mitochondria, useful in a variety of therapeutic regimens for delivery of desirable genetic traits to one or more cells, tissues, and/or organs of interest. Also provided are methods for introducing mitochondria into selected host cells for altering the metabolic phenotype of such host cells using one or more mitochondrially-delivered nucleic acid molecules. The present disclosure is also directed to a method of cellular transplantation, comprising the step of administering to an individual one or more of the polymer functionalized mitochondrial compositions and formulations thereof as described herein.

M3 - Patent

M1 - WO2019028469

ER -

POLYMER-FUNCTIONALIZED MITOCHONDRIAL COMPOSITIONS AND METHODS OF USE IN CELLULAR TRANSPLANTATION AND FOR ALTERING METABOLIC PHENOTYPE

Abstract

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