Polyglutamine Expansion in Huntingtin and Mechanism of DNA Damage Repair Defects in Huntington’s Disease

Keyphrases

• Huntington's Disease 100%
• Polyglutamine Expansion 100%
• Huntingtin 100%
• DNA Damage Repair Defect 100%
• Neurodegenerative Diseases 80%
• DNA Repair Capacity 80%
• DNA Repair 60%
• Strong Correlation 20%
• Aging 20%
• Genomic Instability 20%
• Neurological Diseases 20%
• Cellular Pathways 20%
• New Players 20%
• Repeat Expansion 20%
• DNA Damage Repair 20%
• Genome-wide Association Study 20%
• Normal Physiology 20%
• Polyglutamine Repeat 20%
• Trinucleotide Expansion 20%
• DNA Repair Deficiency 20%
• Defective DNA Repair 20%
• Strong Connections 20%
• Transcription-coupled DNA Repair 20%
• Hereditary Ataxia 20%
• Prodromal Stage 20%

Neuroscience

• DNA Repair 100%
• Polyglutamine 100%
• Huntington's Disease 100%
• Huntingtin 100%
• Neurodegenerative Disorder 36%
• Amino Terminal Sequence 9%
• Nervous System Disorder 9%
• Ataxia 9%
• Genome-Wide Association Study 9%
• Trinucleotide Repeat 9%

Biochemistry, Genetics and Molecular Biology

• DNA Repair 100%
• Huntingtin 100%
• Transcription 27%
• N-Terminus 9%
• Wild Type 9%
• Genome Instability 9%
• Genome-Wide Association Study 9%
• Trinucleotide Repeat Expansion 9%