Polyester fibers can be rendered calcium phosphate-binding by surface functionalization with bisphosphonate groups

Alessandro Polini, Daniela Geta Petre, Michele Iafisco, Sonia de Lacerda Schickert, Anna Tampieri, Jeroen van den Beucken, Sander C.G. Leeuwenburgh

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Fibers are often used as structural elements to improve the mechanical properties of materials such as brittle ceramic matrices by facilitating the dissipation of energy. However, this energy dissipation is mainly controlled by the interface between the two components, and a poorly designed fiber–matrix interface strongly reduces the efficacy of fiber reinforcement. Here, we present a versatile approach to control the affinity of biocompatible fibers to calcium-containing matrices to maximize the efficacy of reinforcement of calcium phosphates-based bioceramics by means of polymeric fibers. To this end, polyester fibers of tunable length were produced by electrospinning and aminolysis, followed by covalent attachment of alendronate, a bisphosphonate molecule with strong calcium-binding affinity, to the surface of the fibers. The proposed method allowed for selective control over the amount of alendronate conjugation, thereby improving the affinity of polyester fibers toward calcium phosphate bioceramics.

Original languageEnglish (US)
Pages (from-to)2335-2342
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume105
Issue number8
DOIs
StatePublished - Aug 1 2017

Keywords

  • bisphosphonate
  • calcium phosphate
  • electrospinning
  • poly-l-lactic acid
  • polyester

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys

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