TY - JOUR
T1 - Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer
AU - Zhong, Xiaoyan
AU - Yang, Kai
AU - Dong, Zhiliang
AU - Yi, Xuan
AU - Wang, Yong
AU - Ge, Cuicui
AU - Zhao, Yuliang
AU - Liu, Zhuang
N1 - Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2015/12/16
Y1 - 2015/12/16
N2 - Development of biodegradable nanomaterials for drug delivery and cancer theranostics has attracted great attention in recent years. In this work, polydopamine (PDA), a biocompatible polymer, is developed as a promising carrier for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy (RIT) and chemotherapy of cancer in one system. It is found that PDA nanoparticles after modification with poly(ethylene glycol) (PEG) can successfully load several different radionuclides such as 99mTc and 131I, as well as an anticancer drug doxorubicin (DOX). While labeling PDA-PEG with 99mTc (99mTc-PDA-PEG) enables in vivo single photon emission computed tomography imaging, nanoparticles co-loaded with 131I and DOX (131I-PDA-PEG/DOX) can be utilized for combined RIT and chemotherapy, which offers effective cancer treatment efficacy in a remarkably synergistic manner, without rendering significant toxicity to the treated animals. Therefore, this study presents an interesting class of biocompatible nanocarriers, which allow the combination of RIT and chemotherapy, the two extensively applied cancer therapeutic strategies, promising for future clinic translations in cancer treatment. Ploydopamine (PDA) nanoparticles as a biocompatible nanocarrier platform are developed for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy and chemotherapy of cancer. Utilizing this synergistic manner, 131I-PDA-poly(ethylene glycol)/doxorubicin nanoparticles exhibited effective cancer treatment efficacy, without rendering significant toxicity to the treated animals.
AB - Development of biodegradable nanomaterials for drug delivery and cancer theranostics has attracted great attention in recent years. In this work, polydopamine (PDA), a biocompatible polymer, is developed as a promising carrier for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy (RIT) and chemotherapy of cancer in one system. It is found that PDA nanoparticles after modification with poly(ethylene glycol) (PEG) can successfully load several different radionuclides such as 99mTc and 131I, as well as an anticancer drug doxorubicin (DOX). While labeling PDA-PEG with 99mTc (99mTc-PDA-PEG) enables in vivo single photon emission computed tomography imaging, nanoparticles co-loaded with 131I and DOX (131I-PDA-PEG/DOX) can be utilized for combined RIT and chemotherapy, which offers effective cancer treatment efficacy in a remarkably synergistic manner, without rendering significant toxicity to the treated animals. Therefore, this study presents an interesting class of biocompatible nanocarriers, which allow the combination of RIT and chemotherapy, the two extensively applied cancer therapeutic strategies, promising for future clinic translations in cancer treatment. Ploydopamine (PDA) nanoparticles as a biocompatible nanocarrier platform are developed for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy and chemotherapy of cancer. Utilizing this synergistic manner, 131I-PDA-poly(ethylene glycol)/doxorubicin nanoparticles exhibited effective cancer treatment efficacy, without rendering significant toxicity to the treated animals.
KW - SPECT imaging
KW - drug delivery
KW - polydopamine
KW - radioisotope therapy
KW - radiolabeling
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U2 - 10.1002/adfm.201503587
DO - 10.1002/adfm.201503587
M3 - Article
AN - SCOPUS:85000502024
SN - 1616-301X
VL - 25
SP - 7327
EP - 7336
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 47
ER -