Polydopamine as a Biocompatible Multifunctional Nanocarrier for Combined Radioisotope Therapy and Chemotherapy of Cancer

Xiaoyan Zhong, Kai Yang, Zhiliang Dong, Xuan Yi, Yong Wang, Cuicui Ge, Yuliang Zhao, Zhuang Liu

Research output: Contribution to journalArticle

147 Scopus citations

Abstract

Development of biodegradable nanomaterials for drug delivery and cancer theranostics has attracted great attention in recent years. In this work, polydopamine (PDA), a biocompatible polymer, is developed as a promising carrier for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy (RIT) and chemotherapy of cancer in one system. It is found that PDA nanoparticles after modification with poly(ethylene glycol) (PEG) can successfully load several different radionuclides such as 99mTc and 131I, as well as an anticancer drug doxorubicin (DOX). While labeling PDA-PEG with 99mTc (99mTc-PDA-PEG) enables in vivo single photon emission computed tomography imaging, nanoparticles co-loaded with 131I and DOX (131I-PDA-PEG/DOX) can be utilized for combined RIT and chemotherapy, which offers effective cancer treatment efficacy in a remarkably synergistic manner, without rendering significant toxicity to the treated animals. Therefore, this study presents an interesting class of biocompatible nanocarriers, which allow the combination of RIT and chemotherapy, the two extensively applied cancer therapeutic strategies, promising for future clinic translations in cancer treatment. Ploydopamine (PDA) nanoparticles as a biocompatible nanocarrier platform are developed for loading of both radionuclides and an anticancer drug to realize nuclear-imaging-guided combined radioisotope therapy and chemotherapy of cancer. Utilizing this synergistic manner, 131I-PDA-poly(ethylene glycol)/doxorubicin nanoparticles exhibited effective cancer treatment efficacy, without rendering significant toxicity to the treated animals.

Original languageEnglish (US)
Pages (from-to)7327-7336
Number of pages10
JournalAdvanced Functional Materials
Volume25
Issue number47
DOIs
StatePublished - Dec 16 2015

Keywords

  • drug delivery
  • polydopamine
  • radioisotope therapy
  • radiolabeling
  • SPECT imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

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