Polycythemia vera: An appraisal of the biology and management 10 years after the discovery of JAK2 V617F

Brady L. Stein, Stephen T. Oh, Dmitriy Berenzon, Gabriela S. Hobbs, Marina Kremyanskaya, Raajit K. Rampal, Camille N. Abboud, Kenneth Adler, Mark L. Heaney, Elias J. Jabbour, Rami S. Komrokji, Alison R. Moliterno, Ellen K. Ritchie, Lawrence Rice, John Mascarenhas, Ronald Hoffman

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


Polycythemia vera (PV) is a chronic myeloproliferative neoplasm that is associated with a substantial symptom burden, thrombohemorrhagic complications, and impaired survival. A decade after the seminal discovery of an activating mutation in the tyrosine kinase JAK2 in nearly all patients with PV, new treatment options are finally beginning to emerge, necessitating a critica reappraisal of the underlying pathogenesis and therapeutic modalities available for PV. Herein, we comprehensively review clinical aspects of PV including diagnostic considerations, natural history, and risk factors for thrombosis. We summarize recent studies delineating the genetic basis of PV, ncluding their implications for evolution to myelofibrosis and secondary acute myeloid leukemia We assess the quality of evidence to support the use of currently available therapies, including aspirin, phlebotomy, hydroxyurea, and interferon. We analyze recent studies evaluating the safety and efficacy of JAK inhibitors, such as ruxolitinib, and evaluate their role in the context of other available therapies for PV. This review provides a framework for practicing hematologists and oncologists to make rational treatment decisions for patients with PV.

Original languageEnglish (US)
Pages (from-to)3953-3960
Number of pages8
JournalJournal of Clinical Oncology
Issue number33
StatePublished - Nov 20 2015

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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