TY - JOUR
T1 - Polychlorinated biphenyls
T2 - Metabolic behavior of pure isomers in pigeons, rats, and brook trout
AU - Hutzinger, O.
AU - Nash, D. M.
AU - Safe, S.
AU - Defreitas, A. S.W.
AU - Norstrom, R. J.
AU - Wildish, D. J.
AU - Zitko, V.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1972
Y1 - 1972
N2 - The metabolic behavior of pure mono-, di-, tetra-, and hexachlorobiphenyl isomers in pigeons, rats, and brook trout was investigated. Excreta from these animals were extracted and examined by chromatographic and mass spectrometric techniques. The results showed conversion of the 4-chloro-, 4,4′-dichloro- , and 2,2′,5,5′-tetrachlorobiphenyl isomers into monohydroxylated derivatives by the rat and pigeon whereas no hydroxymetabolites were detected in the excreta of the brook trout. No hydroxylated products of 2,2′,4,4′,5,5′-hexachlorobiphenyl were detected in the excreta of pigeons, rats, or brook trout.
AB - The metabolic behavior of pure mono-, di-, tetra-, and hexachlorobiphenyl isomers in pigeons, rats, and brook trout was investigated. Excreta from these animals were extracted and examined by chromatographic and mass spectrometric techniques. The results showed conversion of the 4-chloro-, 4,4′-dichloro- , and 2,2′,5,5′-tetrachlorobiphenyl isomers into monohydroxylated derivatives by the rat and pigeon whereas no hydroxymetabolites were detected in the excreta of the brook trout. No hydroxylated products of 2,2′,4,4′,5,5′-hexachlorobiphenyl were detected in the excreta of pigeons, rats, or brook trout.
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U2 - 10.1126/science.178.4058.312
DO - 10.1126/science.178.4058.312
M3 - Article
C2 - 4627870
AN - SCOPUS:0015517718
SN - 0036-8075
VL - 178
SP - 312
EP - 314
JO - Science
JF - Science
IS - 4058
ER -