Polychlorinated biphenyls: Metabolic behavior of pure isomers in pigeons, rats, and brook trout

O. Hutzinger, D. M. Nash, S. Safe, A. S.W. Defreitas, R. J. Norstrom, D. J. Wildish, V. Zitko

Research output: Contribution to journalArticlepeer-review

168 Scopus citations

Abstract

The metabolic behavior of pure mono-, di-, tetra-, and hexachlorobiphenyl isomers in pigeons, rats, and brook trout was investigated. Excreta from these animals were extracted and examined by chromatographic and mass spectrometric techniques. The results showed conversion of the 4-chloro-, 4,4′-dichloro- , and 2,2′,5,5′-tetrachlorobiphenyl isomers into monohydroxylated derivatives by the rat and pigeon whereas no hydroxymetabolites were detected in the excreta of the brook trout. No hydroxylated products of 2,2′,4,4′,5,5′-hexachlorobiphenyl were detected in the excreta of pigeons, rats, or brook trout.

Original languageEnglish (US)
Pages (from-to)312-314
Number of pages3
JournalScience
Volume178
Issue number4058
DOIs
StatePublished - 1972

ASJC Scopus subject areas

  • General

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