Polychlorinated Biphenyls: Congener-Specific Analysis of a Commercial Mixture and a Human Milk Extract

Stephen Safe, Lorna Safe, Michael Mullin

Research output: Contribution to journalArticle

170 Scopus citations

Abstract

On the basis of the relative retention times and response factors of all 209 synthetic polychlorinated biphenyls (PCBs), this paper reports the first congener-specific analysis of a commercial PCB preparation, Aroclor 1260, and the PCB composition of a human milk extract. The analysis indicates that Aroclor 1260 contains nearly 80 different PCB congeners with the major components identified as 2, 2', 3, 4', 5', 6-, 2, 2', 4, 4', 5, 5'-, 2, 2', 3, 4, 5, 5’-, and 2, 2', 3, 4, 4', 5'-hexachlorobiphenyl and 2, 2', 3, 3', 4, 4', 5-, 2, 2', 3, 3', 4, 5, 6'-, 2, 2', 3, 4, 4', 5, 5'-, and 2, 2', 3, 4', 5, 5', 6-heptachlorobiphenyl. In contrast, the major PCB components of the human milk fraction were the 2, 4, 4’-tri-, 2, 4, 4’, 5-tetra-, 2, 2', 4, 4’, 5-penta-, 2, 3', 4, 4’, 5-penta-, 2, 2', 3, 4, 4, 5’-hexa-, 2, 2, 4, 4', 5, 5’-hexa-, 2, 2', 3, 3', 4, 4', 5-hepta-, and 2, 2', 3, 4, 4’, 5, 5’-heptachlorobiphenyls. The significance of congener-specific PCB analysis is discussed in terms of the structure-activity effects on PCB persistence, bioaccumulation, and toxicity.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume33
Issue number1
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

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