Polycation-Mediated Integrated Cell Death Processes

Ladan Parhamifar, Helene Andersen, Linping Wu, Arnaldur Hall, Diana Hudzech, Seyed Moien Moghimi

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Abstract

One of the major challenges in the field of nucleic acid delivery is the design of delivery vehicles with attributes that render them safe as well as efficient in transfection. To this end, polycationic vectors have been intensely investigated with native polyethylenimines (PEIs) being the gold standard. PEIs are highly efficient transfectants, but depending on their architecture and size they induce cytotoxicity through different modes of cell death pathways. Here, we briefly review dynamic and integrated cell death processes and pathways, and discuss considerations in cell death assay design and their interpretation in relation to PEIs and PEI-based engineered vectors, which are also translatable for the design and studying the safety of other transfectants.

Original languageEnglish (US)
Title of host publicationAdvances in Genetics
PublisherAcademic Press
Pages353-398
Number of pages46
DOIs
StatePublished - 2014

Publication series

NameAdvances in Genetics
Volume88
ISSN (Print)0065-2660

Keywords

  • Apoptosis
  • Autophagy
  • Cell death
  • Nanomedicine
  • Necrosis
  • Polycations
  • Polyethylenimine

ASJC Scopus subject areas

  • Genetics

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