Polycation cytotoxicity: A delicate matter for nucleic acid therapy -focus on polyethylenimine

Ladan Parhamifar, Anna K. Larsen, A. Christy Hunter, Thomas L. Andresen, Seyed Moghimi

    Research output: Contribution to journalArticlepeer-review

    204 Scopus citations

    Abstract

    This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery.

    Original languageEnglish (US)
    Pages (from-to)4001-4009
    Number of pages9
    JournalSoft Matter
    Volume6
    Issue number17
    DOIs
    StatePublished - Sep 7 2010

    ASJC Scopus subject areas

    • General Chemistry
    • Condensed Matter Physics

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