Polycation cytotoxicity: A delicate matter for nucleic acid therapy -focus on polyethylenimine

Ladan Parhamifar, Anna K. Larsen, A. Christy Hunter, Thomas L. Andresen, Seyed Moghimi

Research output: Contribution to journalArticlepeer-review

199 Scopus citations


This article provides a critical assessment of the major challenges facing nucleic acid therapeutics, focusing on the safety and efficacy of delivery strategies using synthetic polycations and particularly polyethylenimines. Deficiencies in the field and avenues for further research are identified that could help with design and selection of an expanded and improved library of safer polycationic vectors for clinical gene therapy and RNA interference delivery.

Original languageEnglish (US)
Pages (from-to)4001-4009
Number of pages9
JournalSoft Matter
Issue number17
StatePublished - Sep 7 2010

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics


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