Abstract
A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1250-1254 |
| Number of pages | 5 |
| Journal | Small |
| Volume | 10 |
| Issue number | 7 |
| DOIs | |
| State | Published - Apr 9 2014 |
Keywords
- cancer immunotherapy
- polyarginine
- single-molecule fluorescence imaging
- single-molecule force measurement
ASJC Scopus subject areas
- Biomaterials
- Engineering (miscellaneous)
- Biotechnology
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