Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking

Lin Ping Wu; Danyang Wang; Ladan Parhamifar; Arnaldur Hall; Guo Qiang Chen; Seyed M. Moghimi

doi:10.1002/adhm.201300533

Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking

Lin Ping Wu, Danyang Wang, Ladan Parhamifar, Arnaldur Hall, Guo Qiang Chen, Seyed M. Moghimi

Houston Methodist

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

A simple and highly safe poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticulate delivery system that targets different cell types is developed. A sub-cytotoxic level of polyethylenimine coat mediates universal cell targeting. Internalized nanoparticles traffic along endolysosomal compartments, endoplasmic reticulum and the Golgi complex. Nanoparticles have no detrimental effects on cell morphology and respiration.

Original language	English (US)
Pages (from-to)	817-824
Number of pages	8
Journal	Advanced Healthcare Materials
Volume	3
Issue number	6
DOIs	https://doi.org/10.1002/adhm.201300533
State	Published - Jun 2014

Keywords

Cell targeting
Intracellular trafficking
Polyethylenimine
Polyhydroxyalkanoate
Surface coating

ASJC Scopus subject areas

Biomedical Engineering
Biomaterials
Pharmaceutical Science

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Wu, L. P., Wang, D., Parhamifar, L., Hall, A., Chen, G. Q., & Moghimi, S. M. (2014). Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking. Advanced Healthcare Materials, 3(6), 817-824. https://doi.org/10.1002/adhm.201300533

Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking. / Wu, Lin Ping; Wang, Danyang; Parhamifar, Ladan et al.
In: Advanced Healthcare Materials, Vol. 3, No. 6, 06.2014, p. 817-824.

Research output: Contribution to journal › Article › peer-review

Wu, LP, Wang, D, Parhamifar, L, Hall, A, Chen, GQ & Moghimi, SM 2014, 'Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking', Advanced Healthcare Materials, vol. 3, no. 6, pp. 817-824. https://doi.org/10.1002/adhm.201300533

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Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking

Abstract

Keywords

ASJC Scopus subject areas

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