Poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking

Lin Ping Wu, Danyang Wang, Ladan Parhamifar, Arnaldur Hall, Guo Qiang Chen, Seyed Moghimi

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

A simple and highly safe poly(3-hydroxybutyrate-co-R-3-hydroxyhexanoate) nanoparticulate delivery system that targets different cell types is developed. A sub-cytotoxic level of polyethylenimine coat mediates universal cell targeting. Internalized nanoparticles traffic along endolysosomal compartments, endoplasmic reticulum and the Golgi complex. Nanoparticles have no detrimental effects on cell morphology and respiration.

Original languageEnglish (US)
Pages (from-to)817-824
Number of pages8
JournalAdvanced Healthcare Materials
Volume3
Issue number6
DOIs
StatePublished - Jan 1 2014

Keywords

  • Cell targeting
  • Intracellular trafficking
  • Polyethylenimine
  • Polyhydroxyalkanoate
  • Surface coating

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Pharmaceutical Science

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