Poly(ε-caprolactone) grafted dextran biodegradable electrospun matrix: A novel scaffold for tissue engineering

Madhab Prasad Bajgai; Santosh Aryal; Shanta Raj Bhattarai; K. C.Remant Bahadur; Kawn Woo Kim; Hak Yong Kim

doi:10.1002/app.27825

Poly(ε-caprolactone) grafted dextran biodegradable electrospun matrix: A novel scaffold for tissue engineering

Madhab Prasad Bajgai, Santosh Aryal, Shanta Raj Bhattarai, K. C.Remant Bahadur, Kawn Woo Kim, Hak Yong Kim

Houston Methodist

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The main objective of the present work was to fabricate poly(ε-caprolactone) grafted dextran (PGD) electrospun matrix (matrix) and to investigate the scaffold potential in tissue engineering application. In this work, at first we synthesized PGD polymer via ring opening polymerization (ROP), and with predetermined electrospinning conditions, nanofibrous matrix with high molecular weight PGD (PGD-50, M_w = 45,500) has been successfully fabricated for the first time. Mouse osteoblast like cells, MC3T3 was used to test biocompatibility, assays of cell adhesion, survival, and effects on cell morphology of the matrix. The data demonstrate that PGD-50 matrix represent a suitable substrate for supporting cell proliferation, process outgrowth and migration and as such would be a good material for artificial extra cellular matrix.

Original language	English (US)
Pages (from-to)	1447-1454
Number of pages	8
Journal	Journal of Applied Polymer Science
Volume	108
Issue number	3
DOIs	https://doi.org/10.1002/app.27825
State	Published - Mar 5 2008

Keywords

Biodegradable
Biomaterials
Matrix
Polyester
Polysaccharides

ASJC Scopus subject areas

Polymers and Plastics

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10.1002/app.27825

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title = "Poly(ε-caprolactone) grafted dextran biodegradable electrospun matrix: A novel scaffold for tissue engineering",

abstract = "The main objective of the present work was to fabricate poly(ε-caprolactone) grafted dextran (PGD) electrospun matrix (matrix) and to investigate the scaffold potential in tissue engineering application. In this work, at first we synthesized PGD polymer via ring opening polymerization (ROP), and with predetermined electrospinning conditions, nanofibrous matrix with high molecular weight PGD (PGD-50, Mw = 45,500) has been successfully fabricated for the first time. Mouse osteoblast like cells, MC3T3 was used to test biocompatibility, assays of cell adhesion, survival, and effects on cell morphology of the matrix. The data demonstrate that PGD-50 matrix represent a suitable substrate for supporting cell proliferation, process outgrowth and migration and as such would be a good material for artificial extra cellular matrix.",

keywords = "Biodegradable, Biomaterials, Matrix, Polyester, Polysaccharides",

author = "Bajgai, \{Madhab Prasad\} and Santosh Aryal and Bhattarai, \{Shanta Raj\} and Bahadur, \{K. C.Remant\} and Kim, \{Kawn Woo\} and Kim, \{Hak Yong\}",

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T2 - A novel scaffold for tissue engineering

AU - Bajgai, Madhab Prasad

AU - Aryal, Santosh

AU - Bhattarai, Shanta Raj

AU - Bahadur, K. C.Remant

AU - Kim, Kawn Woo

AU - Kim, Hak Yong

PY - 2008/3/5

Y1 - 2008/3/5

N2 - The main objective of the present work was to fabricate poly(ε-caprolactone) grafted dextran (PGD) electrospun matrix (matrix) and to investigate the scaffold potential in tissue engineering application. In this work, at first we synthesized PGD polymer via ring opening polymerization (ROP), and with predetermined electrospinning conditions, nanofibrous matrix with high molecular weight PGD (PGD-50, Mw = 45,500) has been successfully fabricated for the first time. Mouse osteoblast like cells, MC3T3 was used to test biocompatibility, assays of cell adhesion, survival, and effects on cell morphology of the matrix. The data demonstrate that PGD-50 matrix represent a suitable substrate for supporting cell proliferation, process outgrowth and migration and as such would be a good material for artificial extra cellular matrix.

AB - The main objective of the present work was to fabricate poly(ε-caprolactone) grafted dextran (PGD) electrospun matrix (matrix) and to investigate the scaffold potential in tissue engineering application. In this work, at first we synthesized PGD polymer via ring opening polymerization (ROP), and with predetermined electrospinning conditions, nanofibrous matrix with high molecular weight PGD (PGD-50, Mw = 45,500) has been successfully fabricated for the first time. Mouse osteoblast like cells, MC3T3 was used to test biocompatibility, assays of cell adhesion, survival, and effects on cell morphology of the matrix. The data demonstrate that PGD-50 matrix represent a suitable substrate for supporting cell proliferation, process outgrowth and migration and as such would be a good material for artificial extra cellular matrix.

KW - Biodegradable

KW - Biomaterials

KW - Matrix

KW - Polyester

KW - Polysaccharides

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Poly(ε-caprolactone) grafted dextran biodegradable electrospun matrix: A novel scaffold for tissue engineering

Abstract

Keywords

ASJC Scopus subject areas

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