TY - JOUR
T1 - Poly(ε-caprolactone) grafted dextran biodegradable electrospun matrix
T2 - A novel scaffold for tissue engineering
AU - Bajgai, Madhab Prasad
AU - Aryal, Santosh
AU - Bhattarai, Shanta Raj
AU - Bahadur, K. C.Remant
AU - Kim, Kawn Woo
AU - Kim, Hak Yong
PY - 2008/3/5
Y1 - 2008/3/5
N2 - The main objective of the present work was to fabricate poly(ε-caprolactone) grafted dextran (PGD) electrospun matrix (matrix) and to investigate the scaffold potential in tissue engineering application. In this work, at first we synthesized PGD polymer via ring opening polymerization (ROP), and with predetermined electrospinning conditions, nanofibrous matrix with high molecular weight PGD (PGD-50, Mw = 45,500) has been successfully fabricated for the first time. Mouse osteoblast like cells, MC3T3 was used to test biocompatibility, assays of cell adhesion, survival, and effects on cell morphology of the matrix. The data demonstrate that PGD-50 matrix represent a suitable substrate for supporting cell proliferation, process outgrowth and migration and as such would be a good material for artificial extra cellular matrix.
AB - The main objective of the present work was to fabricate poly(ε-caprolactone) grafted dextran (PGD) electrospun matrix (matrix) and to investigate the scaffold potential in tissue engineering application. In this work, at first we synthesized PGD polymer via ring opening polymerization (ROP), and with predetermined electrospinning conditions, nanofibrous matrix with high molecular weight PGD (PGD-50, Mw = 45,500) has been successfully fabricated for the first time. Mouse osteoblast like cells, MC3T3 was used to test biocompatibility, assays of cell adhesion, survival, and effects on cell morphology of the matrix. The data demonstrate that PGD-50 matrix represent a suitable substrate for supporting cell proliferation, process outgrowth and migration and as such would be a good material for artificial extra cellular matrix.
KW - Biodegradable
KW - Biomaterials
KW - Matrix
KW - Polyester
KW - Polysaccharides
UR - http://www.scopus.com/inward/record.url?scp=42049110729&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42049110729&partnerID=8YFLogxK
U2 - 10.1002/app.27825
DO - 10.1002/app.27825
M3 - Article
AN - SCOPUS:42049110729
VL - 108
SP - 1447
EP - 1454
JO - Journal of Applied Polymer Science
JF - Journal of Applied Polymer Science
SN - 0021-8995
IS - 3
ER -