Polarization and reprogramming of myeloid-derived suppressor cells

Wen Chin Yang, Ge Ma, Shu Hsia Chen, Ping Ying Pan

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Myeloid-derived suppressor cells (MDSC) have recently emerged as one of the central regulators of the immune system. In recent years, interest in understanding MDSC biology and applying MDSC for therapeutic purpose has exploded exponentially. Despite recent progress in MDSC biology, the mechanisms underlying MDSC development from expansion and activation to polarization in different diseases remain poorly understood. More recent studies have demonstrated that two MDSC subsets, M (monocytic)-MDSC and G (granulocytic)-MDSC, are able to polarize from a classically activated phenotype (M1) to an alternatively activated one (M2), or vice versa, in tumor-bearing mice. This phenotypic polarization affects MDSC function and disease progression. In this article, we summarize and discuss polarization, mechanism and therapeutic potential of MDSC. An emphasis is placed on the emerging concept of reprogramming MDSC polarization as a therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)207-209
Number of pages3
JournalJournal of molecular cell biology
Volume5
Issue number3
DOIs
StatePublished - Jun 2013

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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