Point-of-care technologies for molecular diagnostics using a drop of blood

Yujun Song, Yu Yen Huang, Xuewu Liu, Xiaojing Zhang, Mauro Ferrari, Lidong Qin

Research output: Contribution to journalReview article

135 Scopus citations

Abstract

Molecular diagnostics is crucial for prevention, identification, and treatment of disease. Traditional technologies for molecular diagnostics using blood are limited to laboratory use because they rely on sample purification and sophisticated instruments, are labor and time intensive, expensive, and require highly trained operators. This review discusses the frontiers of point-of-care (POC) diagnostic technologies using a drop of blood obtained from a finger prick. These technologies, including emerging biotechnologies, nanotechnologies, and microfluidics, hold the potential for rapid, accurate, and inexpensive disease diagnostics.

Original languageEnglish (US)
Pages (from-to)132-139
Number of pages8
JournalTrends in Biotechnology
Volume32
Issue number3
DOIs
StatePublished - Mar 2014

Keywords

  • Biomolecules
  • Circulating tumor cells
  • Molecular diagnostics
  • Nucleic acids
  • Point-of-care diagnostics
  • Proteins

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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