Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance

James Versalovic; Michael S. Osato; Klaudia Spakovsky; Maria Pina Dore; Rita Reddy; Gregory G. Stone; Dee Shortridge; Robert K. Flamm; S. Ken Tanaka; David Y. Graham

doi:10.1093/jac/40.2.283

Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance

James Versalovic, Michael S. Osato, Klaudia Spakovsky, Maria Pina Dore, Rita Reddy, Gregory G. Stone, Dee Shortridge, Robert K. Flamm, S. Ken Tanaka, David Y. Graham

Research output: Contribution to journal › Article › peer-review

177 Scopus citations

Abstract

Fifty-four of 59 (91.5%) clarithromycin-resistant isolates of Helicobacter pylori from different patients possessed either the A2143G (formerly A2058G) or the A2144G (formerly A2059G) mutation in the gene encoding 23S rRNA. The A2143G mutation was significantly more likely to occur in isolates with MICs exceeding 64 mg/L (65% versus 30% with the A2144G mutation; P = 0.01). The majority (26 of 31; 83.9%) of isolates with the A2143G mutation had MICs exceeding 64 mg/L. Peptic ulcer disease recurred in a substantial proportion of patients infected with H. pylori strains containing either the A2143G or the A2144G mutation.

Original language	English (US)
Pages (from-to)	283-286
Number of pages	4
Journal	Journal of Antimicrobial Chemotherapy
Volume	40
Issue number	2
DOIs	https://doi.org/10.1093/jac/40.2.283
State	Published - Aug 1997

ASJC Scopus subject areas

Pharmacology
Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

Access to Document

10.1093/jac/40.2.283

Cite this

@article{47aa6c70ea3e425b83b0fd04a5191913,

title = "Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance",

abstract = "Fifty-four of 59 (91.5%) clarithromycin-resistant isolates of Helicobacter pylori from different patients possessed either the A2143G (formerly A2058G) or the A2144G (formerly A2059G) mutation in the gene encoding 23S rRNA. The A2143G mutation was significantly more likely to occur in isolates with MICs exceeding 64 mg/L (65% versus 30% with the A2144G mutation; P = 0.01). The majority (26 of 31; 83.9%) of isolates with the A2143G mutation had MICs exceeding 64 mg/L. Peptic ulcer disease recurred in a substantial proportion of patients infected with H. pylori strains containing either the A2143G or the A2144G mutation.",

author = "James Versalovic and Osato, {Michael S.} and Klaudia Spakovsky and Dore, {Maria Pina} and Rita Reddy and Stone, {Gregory G.} and Dee Shortridge and Flamm, {Robert K.} and Tanaka, {S. Ken} and Graham, {David Y.}",

year = "1997",

month = aug,

doi = "10.1093/jac/40.2.283",

language = "English (US)",

volume = "40",

pages = "283--286",

journal = "Journal of Antimicrobial Chemotherapy",

issn = "0305-7453",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance

AU - Versalovic, James

AU - Osato, Michael S.

AU - Spakovsky, Klaudia

AU - Dore, Maria Pina

AU - Reddy, Rita

AU - Stone, Gregory G.

AU - Shortridge, Dee

AU - Flamm, Robert K.

AU - Tanaka, S. Ken

AU - Graham, David Y.

PY - 1997/8

Y1 - 1997/8

N2 - Fifty-four of 59 (91.5%) clarithromycin-resistant isolates of Helicobacter pylori from different patients possessed either the A2143G (formerly A2058G) or the A2144G (formerly A2059G) mutation in the gene encoding 23S rRNA. The A2143G mutation was significantly more likely to occur in isolates with MICs exceeding 64 mg/L (65% versus 30% with the A2144G mutation; P = 0.01). The majority (26 of 31; 83.9%) of isolates with the A2143G mutation had MICs exceeding 64 mg/L. Peptic ulcer disease recurred in a substantial proportion of patients infected with H. pylori strains containing either the A2143G or the A2144G mutation.

AB - Fifty-four of 59 (91.5%) clarithromycin-resistant isolates of Helicobacter pylori from different patients possessed either the A2143G (formerly A2058G) or the A2144G (formerly A2059G) mutation in the gene encoding 23S rRNA. The A2143G mutation was significantly more likely to occur in isolates with MICs exceeding 64 mg/L (65% versus 30% with the A2144G mutation; P = 0.01). The majority (26 of 31; 83.9%) of isolates with the A2143G mutation had MICs exceeding 64 mg/L. Peptic ulcer disease recurred in a substantial proportion of patients infected with H. pylori strains containing either the A2143G or the A2144G mutation.

UR - http://www.scopus.com/inward/record.url?scp=0030770494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030770494&partnerID=8YFLogxK

U2 - 10.1093/jac/40.2.283

DO - 10.1093/jac/40.2.283

M3 - Article

C2 - 9301997

AN - SCOPUS:0030770494

VL - 40

SP - 283

EP - 286

JO - Journal of Antimicrobial Chemotherapy

JF - Journal of Antimicrobial Chemotherapy

SN - 0305-7453

IS - 2

ER -

Point mutations in the 23S rRNA gene of Helicobacter pylori associated with different levels of clarithromycin resistance

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this