Abstract
A diffuse xanthomatous infiltration was detected on a biopsy of the hyperpigmented patches in a 40-year-old man with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome. Multiple biopsies of the hyperpigmented patches showed diffuse or perivascular foamy histiocytes in the upper and mid dermis, a sparse infiltrate of lymphocytes, fibrosis, hyperpigmentation of the basal layer, and capillary proliferation. The foamy cells were positive for periodic acid-Schiff (PAS) with diastase, oil red-O, and CD68. To our knowledge, this is the first case with foamy histiocytes without xanthomatous-appearing skin lesions in POEMS syndrome. It would be worth searching for xanthomatous histiocytes in the hyperpigmented skin of patients with POEMS syndrome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 567-570 |
| Number of pages | 4 |
| Journal | American Journal of Dermatopathology |
| Volume | 21 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1999 |
Keywords
- POEMS syndrome
- Xanthomatous infiltration
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Dermatology
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