TY - JOUR
T1 - POEMS syndrome with xanthomatous cells
AU - Chang, Sung Eun
AU - Choi, Jee Ho
AU - Sung, Kyung Jeh
AU - Moon, Kee Chan
AU - Koh, Jai Kyoung
AU - Ro, Jae
PY - 1999/1/1
Y1 - 1999/1/1
N2 - A diffuse xanthomatous infiltration was detected on a biopsy of the hyperpigmented patches in a 40-year-old man with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome. Multiple biopsies of the hyperpigmented patches showed diffuse or perivascular foamy histiocytes in the upper and mid dermis, a sparse infiltrate of lymphocytes, fibrosis, hyperpigmentation of the basal layer, and capillary proliferation. The foamy cells were positive for periodic acid-Schiff (PAS) with diastase, oil red-O, and CD68. To our knowledge, this is the first case with foamy histiocytes without xanthomatous-appearing skin lesions in POEMS syndrome. It would be worth searching for xanthomatous histiocytes in the hyperpigmented skin of patients with POEMS syndrome.
AB - A diffuse xanthomatous infiltration was detected on a biopsy of the hyperpigmented patches in a 40-year-old man with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome. Multiple biopsies of the hyperpigmented patches showed diffuse or perivascular foamy histiocytes in the upper and mid dermis, a sparse infiltrate of lymphocytes, fibrosis, hyperpigmentation of the basal layer, and capillary proliferation. The foamy cells were positive for periodic acid-Schiff (PAS) with diastase, oil red-O, and CD68. To our knowledge, this is the first case with foamy histiocytes without xanthomatous-appearing skin lesions in POEMS syndrome. It would be worth searching for xanthomatous histiocytes in the hyperpigmented skin of patients with POEMS syndrome.
KW - POEMS syndrome
KW - Xanthomatous infiltration
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U2 - 10.1097/00000372-199912000-00012
DO - 10.1097/00000372-199912000-00012
M3 - Article
C2 - 10608252
AN - SCOPUS:0344577849
SN - 0193-1091
VL - 21
SP - 567
EP - 570
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 6
ER -