POEMS syndrome with xanthomatous cells

Sung Eun Chang, Jee Ho Choi, Kyung Jeh Sung, Kee Chan Moon, Jai Kyoung Koh, Jae Ro

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A diffuse xanthomatous infiltration was detected on a biopsy of the hyperpigmented patches in a 40-year-old man with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome. Multiple biopsies of the hyperpigmented patches showed diffuse or perivascular foamy histiocytes in the upper and mid dermis, a sparse infiltrate of lymphocytes, fibrosis, hyperpigmentation of the basal layer, and capillary proliferation. The foamy cells were positive for periodic acid-Schiff (PAS) with diastase, oil red-O, and CD68. To our knowledge, this is the first case with foamy histiocytes without xanthomatous-appearing skin lesions in POEMS syndrome. It would be worth searching for xanthomatous histiocytes in the hyperpigmented skin of patients with POEMS syndrome.

Original languageEnglish (US)
Pages (from-to)567-570
Number of pages4
JournalAmerican Journal of Dermatopathology
Issue number6
StatePublished - Jan 1 1999


  • POEMS syndrome
  • Xanthomatous infiltration

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology


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