POEMS syndrome with xanthomatous cells

Sung Eun Chang; Jee Ho Choi; Kyung Jeh Sung; Kee Chan Moon; Jai Kyoung Koh; Jae Ro

doi:10.1097/00000372-199912000-00012

POEMS syndrome with xanthomatous cells

Sung Eun Chang, Jee Ho Choi, Kyung Jeh Sung, Kee Chan Moon, Jai Kyoung Koh, Jae Ro

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

A diffuse xanthomatous infiltration was detected on a biopsy of the hyperpigmented patches in a 40-year-old man with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome. Multiple biopsies of the hyperpigmented patches showed diffuse or perivascular foamy histiocytes in the upper and mid dermis, a sparse infiltrate of lymphocytes, fibrosis, hyperpigmentation of the basal layer, and capillary proliferation. The foamy cells were positive for periodic acid-Schiff (PAS) with diastase, oil red-O, and CD68. To our knowledge, this is the first case with foamy histiocytes without xanthomatous-appearing skin lesions in POEMS syndrome. It would be worth searching for xanthomatous histiocytes in the hyperpigmented skin of patients with POEMS syndrome.

Original language	English (US)
Pages (from-to)	567-570
Number of pages	4
Journal	American Journal of Dermatopathology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1097/00000372-199912000-00012
State	Published - Jan 1 1999

Keywords

POEMS syndrome
Xanthomatous infiltration

ASJC Scopus subject areas

Pathology and Forensic Medicine
Dermatology

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@article{2480fc78d7034434a804cd35f76316fe,

title = "POEMS syndrome with xanthomatous cells",

abstract = "A diffuse xanthomatous infiltration was detected on a biopsy of the hyperpigmented patches in a 40-year-old man with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome. Multiple biopsies of the hyperpigmented patches showed diffuse or perivascular foamy histiocytes in the upper and mid dermis, a sparse infiltrate of lymphocytes, fibrosis, hyperpigmentation of the basal layer, and capillary proliferation. The foamy cells were positive for periodic acid-Schiff (PAS) with diastase, oil red-O, and CD68. To our knowledge, this is the first case with foamy histiocytes without xanthomatous-appearing skin lesions in POEMS syndrome. It would be worth searching for xanthomatous histiocytes in the hyperpigmented skin of patients with POEMS syndrome.",

keywords = "POEMS syndrome, Xanthomatous infiltration",

author = "Chang, {Sung Eun} and Choi, {Jee Ho} and Sung, {Kyung Jeh} and Moon, {Kee Chan} and Koh, {Jai Kyoung} and Jae Ro",

year = "1999",

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language = "English (US)",

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journal = "American Journal of Dermatopathology",

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T1 - POEMS syndrome with xanthomatous cells

AU - Chang, Sung Eun

AU - Choi, Jee Ho

AU - Sung, Kyung Jeh

AU - Moon, Kee Chan

AU - Koh, Jai Kyoung

AU - Ro, Jae

PY - 1999/1/1

Y1 - 1999/1/1

N2 - A diffuse xanthomatous infiltration was detected on a biopsy of the hyperpigmented patches in a 40-year-old man with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome. Multiple biopsies of the hyperpigmented patches showed diffuse or perivascular foamy histiocytes in the upper and mid dermis, a sparse infiltrate of lymphocytes, fibrosis, hyperpigmentation of the basal layer, and capillary proliferation. The foamy cells were positive for periodic acid-Schiff (PAS) with diastase, oil red-O, and CD68. To our knowledge, this is the first case with foamy histiocytes without xanthomatous-appearing skin lesions in POEMS syndrome. It would be worth searching for xanthomatous histiocytes in the hyperpigmented skin of patients with POEMS syndrome.

AB - A diffuse xanthomatous infiltration was detected on a biopsy of the hyperpigmented patches in a 40-year-old man with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, M-protein, Skin changes) syndrome. Multiple biopsies of the hyperpigmented patches showed diffuse or perivascular foamy histiocytes in the upper and mid dermis, a sparse infiltrate of lymphocytes, fibrosis, hyperpigmentation of the basal layer, and capillary proliferation. The foamy cells were positive for periodic acid-Schiff (PAS) with diastase, oil red-O, and CD68. To our knowledge, this is the first case with foamy histiocytes without xanthomatous-appearing skin lesions in POEMS syndrome. It would be worth searching for xanthomatous histiocytes in the hyperpigmented skin of patients with POEMS syndrome.

KW - POEMS syndrome

KW - Xanthomatous infiltration

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