TY - JOUR
T1 - POEMS Syndrome
T2 - Studies in a Patient with an IgG-κ M Protein but No Polyneuropathy
AU - Morrow, Jay S.
AU - Schaefer, Ernst J.
AU - Huston, David P.
AU - Rosen, Saul W.
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1982/6
Y1 - 1982/6
N2 - A 48-year-old woman had a variation of the syndrome of polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (the so-called POEMS syndrome). The patient's neurological findings were entirely normal, but she had splenomegaly, hyperprolactinemia with galactorrhea and oligomenorrhea, a thyroid nodule with evidence of mild thyroiditis on aspiration biopsy specimen, an IgG-κ monoclonal gammopathy, and hyperpigmentation and thickening of the skin. A short course of plasmapheresis (twelve 4-L exchanges in one month) did not alter any of the clinical abnormalities, but did result in a 70% decrease in the monoclonal IgG level (from 2.2 to 0.7 g/dL).
AB - A 48-year-old woman had a variation of the syndrome of polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (the so-called POEMS syndrome). The patient's neurological findings were entirely normal, but she had splenomegaly, hyperprolactinemia with galactorrhea and oligomenorrhea, a thyroid nodule with evidence of mild thyroiditis on aspiration biopsy specimen, an IgG-κ monoclonal gammopathy, and hyperpigmentation and thickening of the skin. A short course of plasmapheresis (twelve 4-L exchanges in one month) did not alter any of the clinical abnormalities, but did result in a 70% decrease in the monoclonal IgG level (from 2.2 to 0.7 g/dL).
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U2 - 10.1001/archinte.142.6.1231
DO - 10.1001/archinte.142.6.1231
M3 - Article
C2 - 6807233
AN - SCOPUS:85047692842
SN - 0003-9926
VL - 142
SP - 1231
EP - 1234
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 6
ER -