POEMS Syndrome: Studies in a Patient with an IgG-κ M Protein but No Polyneuropathy

Jay S. Morrow, Ernst J. Schaefer, David P. Huston, Saul W. Rosen

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28 Scopus citations


A 48-year-old woman had a variation of the syndrome of polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes (the so-called POEMS syndrome). The patient's neurological findings were entirely normal, but she had splenomegaly, hyperprolactinemia with galactorrhea and oligomenorrhea, a thyroid nodule with evidence of mild thyroiditis on aspiration biopsy specimen, an IgG-κ monoclonal gammopathy, and hyperpigmentation and thickening of the skin. A short course of plasmapheresis (twelve 4-L exchanges in one month) did not alter any of the clinical abnormalities, but did result in a 70% decrease in the monoclonal IgG level (from 2.2 to 0.7 g/dL).

Original languageEnglish (US)
Pages (from-to)1231-1234
Number of pages4
JournalArchives of Internal Medicine
Issue number6
StatePublished - Jun 1982

ASJC Scopus subject areas

  • Internal Medicine


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