Pneumococcal endocarditis in children

Laurence B. Givner, Edward O. Mason, Tina Q. Tan, William J. Barson, Gordon E. Schutze, Ellen R. Wald, John S. Bradley, Jill Hoffman, Ram Yogev, Sheldon L. Kaplan

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Endocarditis due to Streptococcus pneumoniae is unusual in children, accounting for 3%-7% of all cases of childhood endocarditis. The US Pediatric Multicenter Pneumococcal Surveillance Group has prospectively identified patients with invasive disease at 8 children's hospitals. During the period of 1 September 1993 through 28 February 2003, a total of 11 children with pneumococcal endocarditis were seen. Seven (64%) were 3-36 months old; 8 (73%) were boys. Ten (91%) had preexisting structural heart disease; 5 had undergone previous heart surgery. Concomitant sites of infection were noted in 6 patients (55%), including 3 patients with meningitis. One patient (9%) died during hospitalization, and 5 others (45%) experienced serious complications. Only 2 patients remained hospitalized for their entire course of parenteral antibiotic therapy. Eight of 10 pneumococcal isolates tested were vaccine or vaccine-related serotypes included in the currently licensed 7-valent conjugated pneumococcal vaccine. Pneumococcal endocarditis in children is unusual but often has serious complications.

Original languageEnglish (US)
Pages (from-to)1273-1278
Number of pages6
JournalClinical Infectious Diseases
Issue number9
StatePublished - May 1 2004

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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