Ploidy studies by image analysis on fine needle aspirates of the breast

S. R. Taylor, S. Zachariah, S. Chakraborty, J. Overstreet, I. Ramzy, Dina R. Mody

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Quantitative DNA analysis was performed on preoperative fine needle aspirates of 12 breast cancers and 1 benign lesion using the Cell Analysis Systems (CAS) Model 200 image analysis system. The smears were prepared on CAS slides, routinely processed for Papanicolaou staining, and then destained and restained with Feulgen stain after cytologic evaluation. Four cases were DNA diploid, 3 were tetraploid, 1 was diploid/tetraploid, and 5 were aneuploid. When compared to analysis of samples from the resected tumor, both DNA index and S-phase fraction were constant.

Original languageEnglish (US)
Pages (from-to)923-928
Number of pages6
JournalActa Cytologica
Volume37
Issue number6
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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