Platelet pathophysiology, pharmacology, and function in coronary artery disease

Homam Ibrahim, Neal S. Kleiman

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Platelets play a key role in the pathophysiology of coronary artery disease and acute coronary syndromes. Our understanding of platelet function in thrombus formation has increased considerably, resulting in the development of clinically effective treatment strategies and identification of new targets. An underappreciated platelet function is their contribution toward acute and chronic inflammatory processes including atherogenesis. In this review, we discuss the role of platelets in atherosclerosis and thrombosis, platelet function testing, and the pharmacology of currently available antiplatelet drugs.

Original languageEnglish (US)
Pages (from-to)614-623
Number of pages10
JournalCoronary Artery Disease
Volume28
Issue number7
DOIs
StatePublished - 2017

Keywords

  • Antiplatelet drugs
  • Platelet function testing
  • Platelets
  • Thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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